Proton T2 relaxation time of J-coupled cerebral metabolites in rat brain at 9.4 T.
Details
Serval ID
serval:BIB_CF96A14C588B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Proton T2 relaxation time of J-coupled cerebral metabolites in rat brain at 9.4 T.
Journal
NMR in Biomedicine
ISSN
0952-3480 (Print)
ISSN-L
0952-3480
Publication state
Published
Issued date
2008
Volume
21
Number
4
Pages
396-401
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Knowledge of proton T2 relaxation time of metabolites is essential for proper quantitation of metabolite concentrations in localized proton spectroscopy, especially at moderate to long TEs. Although the T2 relaxation time of singlets, such as that of creatine and N-acetylaspartate, has been characterized in several studies, similar information is lacking from coupled spin resonances of cerebral metabolites. In this study, the T2 relaxation time of coupled spin resonances and singlet resonances of cerebral metabolites was measured in rat brain in vivo at 9.4 T. Spectra were acquired at 11 TEs using the SPin ECho, full Intensity Acquired Localized (SPECIAL) spectroscopy method. Data analysis was performed in the frequency domain with the LCModel software using simulated TE-specific basis sets. The T2 relaxation times in compounds showing singlet resonances were 113 +/- 3 ms (total creatine), 178 +/- 29 ms (total choline) and 202 +/- 12 ms (N-acetylaspartate). The T2 values of J-coupled metabolites ranged from 89 +/- 8 ms (glutamate) to 148 +/- 14 ms (myo-inositol).
Keywords
Animals, Brain/metabolism, Computer Simulation, Creatine/metabolism, Glutamic Acid/metabolism, Inositol/metabolism, Magnetic Resonance Spectroscopy, Protons, Rats, Rats, Sprague-Dawley, Taurine/metabolism, Time Factors, Water
Pubmed
Web of science
Create date
04/08/2010 16:28
Last modification date
20/08/2019 16:50