Global genetic differentiation of complex traits shaped by natural selection in humans.

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Version: Final published version
Serval ID
serval:BIB_CF8AC0B8B126
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Global genetic differentiation of complex traits shaped by natural selection in humans.
Journal
Nature communications
Author(s)
Guo J., Wu Y., Zhu Z., Zheng Z., Trzaskowski M., Zeng J., Robinson M.R., Visscher P.M., Yang J.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
14/05/2018
Peer-reviewed
Oui
Volume
9
Number
1
Pages
1865
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
There are mean differences in complex traits among global human populations. We hypothesize that part of the phenotypic differentiation is due to natural selection. To address this hypothesis, we assess the differentiation in allele frequencies of trait-associated SNPs among African, Eastern Asian, and European populations for ten complex traits using data of large sample size (up to ~405,000). We show that SNPs associated with height ([Formula: see text]), waist-to-hip ratio ([Formula: see text]), and schizophrenia ([Formula: see text]) are significantly more differentiated among populations than matched "control" SNPs, suggesting that these trait-associated SNPs have undergone natural selection. We further find that SNPs associated with height ([Formula: see text]) and schizophrenia ([Formula: see text]) show significantly higher variance in linkage disequilibrium (LD) scores across populations than control SNPs. Our results support the hypothesis that natural selection has shaped the genetic differentiation of complex traits, such as height and schizophrenia, among worldwide populations.
Keywords
African Continental Ancestry Group, Alleles, Asian Continental Ancestry Group, Body Height, European Continental Ancestry Group, Gene Frequency, Genome, Human, Genome-Wide Association Study, Humans, Linkage Disequilibrium, Phenotype, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Quantitative Trait, Heritable, Sample Size, Schizophrenia/ethnology, Schizophrenia/genetics, Schizophrenia/pathology, Selection, Genetic, Waist-Hip Ratio
Pubmed
Web of science
Open Access
Yes
Create date
17/05/2018 17:29
Last modification date
20/08/2019 15:49
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