T and B lymphocytes exert distinct effects on the homeostasis of NK cells.
Details
Serval ID
serval:BIB_CF85EE48500A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
T and B lymphocytes exert distinct effects on the homeostasis of NK cells.
Journal
European journal of immunology
ISSN
0014-2980
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
36
Number
10
Pages
2725-2734
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
There is growing evidence that lymphocytes impact the development and/or function of other lymphocyte populations. Based on such observations we have tested whether the NK cell compartment was phenotypically and functionally altered in the absence of B and/or T cells. Here we show that T cell deficiency significantly accelerates BM NK cell production and the subsequent seeding of splenic and liver NK cell compartments. In contrast, B cell deficiency reduces splenic NK cell survival. In the absence of T and B cells, the size of the NK cell compartments is determined by the combination of these positive and negative effects. Even though NK cell homeostasis is significantly altered, NK cells from T and/or B cell-deficient mice show a normal capacity to kill a susceptible target cell line and to produce IFN. Nevertheless, we noted that the usage of MHC class I-specific Ly49 family receptors was significantly altered in the absence of T and/or B cells. In general, B cell deficiency expanded Ly49 receptor usage, while T cell deficiency exerted both positive and negative effects. These findings show that B and T cells significantly and differentially influence the homeostasis and the phenotype of NK cells.
Keywords
Adoptive Transfer, Animals, Antigens, Ly/immunology, Antigens, Ly/metabolism, B-Lymphocytes/immunology, Bone Marrow/immunology, Cell Differentiation/immunology, Flow Cytometry, Histocompatibility Antigens Class I/immunology, Histocompatibility Antigens Class I/metabolism, Homeostasis/immunology, Killer Cells, Natural/cytology, Killer Cells, Natural/immunology, Lectins, C-Type/immunology, Lectins, C-Type/metabolism, Lymphocyte Activation/immunology, Lymphocyte Subsets/cytology, Lymphocyte Subsets/immunology, Mice, Mice, Inbred C57BL, Mice, Knockout, Phenotype, Receptors, NK Cell Lectin-Like, Spleen/cytology, Spleen/immunology, T-Lymphocytes/immunology
Pubmed
Web of science
Open Access
Yes
Create date
17/01/2008 16:24
Last modification date
20/08/2019 16:49