This case report presents an instance of iatrogenic right ventricular perforation during pericardial paracentesis, a rare complication with potentially fatal consequences. Despite initial unsuccessful pericardial drainage, successful closure of the perforation was achieved using an Angio-Seal vascular closure device, leading to cessation of hemorrhage and resolution of hemodynamic instability. The case highlights the efficacy of Angio-Seal in managing such complications, emphasizing its utility in complex clinical scenarios involving pericardial interventions.