Cortical control of saccades and fixation in man. A PET study.

Details

Serval ID
serval:BIB_CF7F0AB256C0
Type
Article: article from journal or magazin.
Collection
Publications
Title
Cortical control of saccades and fixation in man. A PET study.
Journal
Brain
Author(s)
Anderson T.J., Jenkins I.H., Brooks D.J., Hawken M.B., Frackowiak R.S., Kennard C.
ISSN
0006-8950 (Print)
ISSN-L
0006-8950
Publication state
Published
Issued date
1994
Volume
117 ( Pt 5)
Pages
1073-1084
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
To identify cortical regions activated during saccades and visual fixation, regional cerebral blood flow (rCBF) was measured in eight healthy subjects using C15O2 PET during the performance of three tasks: (i) central fixation; (ii) reflexive saccades to random targets; (iii) remembered saccades to locations of recent target appearance. Significant rCBF increases were identified using analysis of covariance and the t statistic (P < 0.001). Compared with central fixation there was activation of striate and extra-striate cortex, posterior parietal cortex (PPC) and frontal eye fields (FEF) during both reflexive and remembered saccades. During remembered saccades there was additional activation of supplementary motor area (SMA), insula, cingulate, thalamus, midbrain, cerebellum and right superior temporal gyrus (Brodmann's area 22). Compared with the individual saccadic tasks, central fixation activated extensive regions of ventromedial (areas 10, 11 and 32) and anterolateral (areas 8, 9, 10, 45 and 46) prefrontal cortex, and foveal visual cortex. We conclude that FEF and PPC are associated with the generation of both reflexive and remembered saccades, with SMA additionally involved during remembered saccades. Sustained voluntary fixation is mediated by prefrontal cortex.
Keywords
Adult, Cerebral Cortex/physiology, Cerebral Cortex/radionuclide imaging, Fixation, Ocular/physiology, Humans, Male, Reflex, Saccades/physiology, Tomography, Emission-Computed, Visual Cortex/physiology
Pubmed
Web of science
Create date
16/09/2011 21:35
Last modification date
20/08/2019 16:49
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