HIV rebounds from latently infected cells, rather than from continuing low-level replication.

Details

Serval ID
serval:BIB_CF6F06658C27
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
HIV rebounds from latently infected cells, rather than from continuing low-level replication.
Journal
Proceedings of the National Academy of Sciences of the United States of America
Author(s)
Joos B., Fischer M., Kuster H., Pillai S.K., Wong J.K., Böni J., Hirschel B., Weber R., Trkola A., Günthard H.F.
Working group(s)
Swiss HIV Cohort Study
Contributor(s)
Battegay M., Bernasconi E., Böni J., Bucher HC., Bürgisser P., Calmy A., Cattacin S., Cavassini M., Dubs R., Egger M., Elzi L., Fischer M., Flepp M., Fontana A., Francioli P., Furrer H., Fux C., Gorgievski M., Günthard H., Hirsch H., Hirschel B., Hösli I., Kahlert Ch., Kaiser L., Karrer U., Kind C., Klimkait T., Ledergerber B., Martinetti G., Martinez B., Müller N., Nadal D., Paccaud F., Pantaleo G., Rauch A., Regenass S., Rickenbach M., Rudin C., Schmid P., Schultze D., Schüpbach J., Speck R., Taffé P., Telenti A., Trkola A., Vernazza P., Weber R., Yerly S.
ISSN
1091-6490 (Electronic)
ISSN-L
0027-8424
Publication state
Published
Issued date
10/2008
Peer-reviewed
Oui
Volume
105
Number
43
Pages
16725-16730
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Rapid rebound of plasma viremia in patients after interruption of long-term combination antiretroviral therapy (cART) suggests persistence of low-level replicating cells or rapid reactivation of latently infected cells. To further characterize rebounding virus, we performed extensive longitudinal clonal evolutionary studies of HIV env C2-V3-C3 regions and exploited the temporal relationships of rebounding plasma viruses with regard to pretreatment sequences in 20 chronically HIV-1-infected patients having undergone multiple 2-week structured treatment interruptions (STI). Rebounding virus during the short STI was homogeneous, suggesting mono- or oligoclonal origin during reactivation. No evidence for a temporal structure of rebounding virus in regard to pretreatment sequences was found. Furthermore, expansion of distinct lineages at different STI cycles emerged. Together, these findings imply stochastic reactivation of different clones from long-lived latently infected cells rather than expansion of viral populations replicating at low levels. After treatment was stopped, diversity increased steadily, but pretreatment diversity was, on average, achieved only >2.5 years after the start of STI when marked divergence from preexisting quasispecies also emerged. In summary, our results argue against persistence of ongoing low-level replication in patients on suppressive cART. Furthermore, a prolonged delay in restoration of pretreatment viral diversity after treatment interruption demonstrates a surprisingly sustained evolutionary bottleneck induced by punctuated antiretroviral therapy.
Keywords
Cells, Cultured, Genetic Variation, HIV/genetics, HIV/physiology, HIV Infections/drug therapy, HIV Infections/virology, Humans, Molecular Sequence Data, Phylogeny, Receptors, CXCR4, Receptors, HIV, Virus Activation, Virus Latency/drug effects, Virus Replication/drug effects
Pubmed
Web of science
Open Access
Yes
Create date
05/03/2009 16:26
Last modification date
20/08/2019 15:49
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