Redox and Immune Signaling in Schizophrenia: New Therapeutic Potential.

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State: Public
Version: Final published version
License: CC BY-NC 4.0
Serval ID
serval:BIB_CF6CBA8233D2
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Redox and Immune Signaling in Schizophrenia: New Therapeutic Potential.
Journal
The international journal of neuropsychopharmacology
Author(s)
Dwir D., Khadimallah I., Xin L., Rahman M., Du F., Öngür D., Do K.Q.
ISSN
1469-5111 (Electronic)
ISSN-L
1461-1457
Publication state
Published
Issued date
31/05/2023
Peer-reviewed
Oui
Volume
26
Number
5
Pages
309-321
Language
english
Notes
Publication types: Review ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
Publication Status: ppublish
Abstract
Redox biology and immune signaling play major roles in the body, including in brain function. A rapidly growing literature also suggests that redox and immune abnormalities are implicated in neuropsychiatric conditions such as schizophrenia (SZ), bipolar disorder, autism, and epilepsy. In this article we review this literature, its implications for the pathophysiology of SZ, and the potential for development of novel treatment interventions targeting redox and immune signaling. Redox biology and immune signaling in the brain are complex and not fully understood; in addition, there are discrepancies in the literature, especially in patient-oriented studies. Nevertheless, it is clear that abnormalities arise in SZ from an interaction between genetic and environmental factors during sensitive periods of brain development, and these abnormalities disrupt local circuits and long-range connectivity. Interventions that correct these abnormalities may be effective in normalizing brain function in psychotic disorders, especially in early phases of illness.
Keywords
Humans, Schizophrenia/drug therapy, Schizophrenia/genetics, Oxidative Stress/physiology, Psychotic Disorders, Oxidation-Reduction, Bipolar Disorder, NAD/NADH, Oxidative stress, glutathione, neuro-inflammation, parvalbumin neurons, schizophrenia
Pubmed
Web of science
Open Access
Yes
Create date
03/04/2023 11:50
Last modification date
09/08/2024 16:06
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