Early drop of circulating T cells negatively correlates with the protective immune response to Yellow Fever vaccination.

Details

Serval ID
serval:BIB_CF63CEAB6BA5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Early drop of circulating T cells negatively correlates with the protective immune response to Yellow Fever vaccination.
Journal
Human vaccines & immunotherapeutics
Author(s)
Bovay A., Speiser D.E., Fuertes Marraco S.A.
ISSN
2164-554X (Electronic)
ISSN-L
2164-5515
Publication state
Published
Issued date
01/12/2020
Peer-reviewed
Oui
Volume
16
Number
12
Pages
3103-3110
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Lymphocyte recirculation within the human body is essential for efficient pathogen detection and immune responses. So far, immune cell migration has been investigated largely using ovine and murine models, with little evidence in humans. Here, we analyzed peripheral blood of healthy individuals following primary vaccination with the Yellow Fever vaccine YF-17D. We found that the number of leukocytes was transiently and sharply reduced in blood as detected on day 7 after vaccine administration. The T cell drop was restricted to cells expressing the lymph node-homing chemokine receptor CCR7. Interestingly, the vaccine-induced drop positively correlated with the expression of CD69 by the T cells before vaccination. This suggests that CCR7 <sup>+</sup> T cells are being trapped within the lymph nodes through CD69-induced suppression of egress. Strikingly, we further found that the T cell drop negatively correlated with CD8 T cell activation and with production of neutralizing antibodies. In conclusion, early and transient T cell depletion in blood negatively correlated with protective immune response events induced by YF-17D vaccination. Our data highlight baseline CD69 expression and early drop in T cells as potential biomarkers of the Yellow Fever vaccine response.
Keywords
T Lymphocytes, Yellow Fever Virus YF-17D vaccine, immune activation, immune protection, lymph Node trapping, neutralizing antibodies
Pubmed
Web of science
Open Access
Yes
Create date
02/05/2020 14:46
Last modification date
20/01/2021 7:24
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