Adipose reduction in the activity of the repressor ICER is responsible for insulin resistance elicited by the transcriptional factors CREB in obesity

Details

Serval ID
serval:BIB_CF1E6CE3338C
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Adipose reduction in the activity of the repressor ICER is responsible for insulin resistance elicited by the transcriptional factors CREB in obesity
Title of the conference
46th Annual Meeting of the European Association for the Study of Diabetes (EASD)
Author(s)
Favre D., Legouil E., Verdumo C., Fahmi D., Regazzi R., Vollenweider P., Giusti V., Waeber G., Abderrahmani A.
Address
Stockholm, Sweden, September 20-24, 2010
ISBN
0012-186X
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
53
Series
Diabetologia
Pages
318
Language
english
Notes
Meeting Abstract: 799
Abstract
BACKGROUND AND AIMS: Sustained adipose activation of the transcriptional activators cAMP response binding proteins (CREB) in obesity leads to impaired expression of the glucose transporter GLUT4 and adiponectin (adipoq) in mice model of obesity. Diminution of GLUT4 and adipoq caused by CREB is indirect and relies on the increased repressive activity of the CREB target gene activating transcription factor 3 (ATF3). Specific inactivation of CREB in adipocytes decreases ATF3 production and improves whole-body insulin sensitivity of mice in the context of diet-induced obesity. Thus, elevation of CREB activity is a key mechanism responsible for adipocyte dysfunction and systemic insulin resistance. The inducible cAMP early repressor (ICER) is a negative regulator of the CREB activity. In fact, ICER antagonizes the CREB factor by competing for the regulation of similar target ge