Neurobiology of DHEA and effects on sexuality, mood and cognition.

Details

Serval ID
serval:BIB_CF11C24FD92D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Neurobiology of DHEA and effects on sexuality, mood and cognition.
Journal
The Journal of steroid biochemistry and molecular biology
Author(s)
Pluchino N., Drakopoulos P., Bianchi-Demicheli F., Wenger J.M., Petignat P., Genazzani A.R.
ISSN
1879-1220 (Electronic)
ISSN-L
0960-0760
Publication state
Published
Issued date
01/2015
Peer-reviewed
Oui
Volume
145
Pages
273-280
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Dehydroepiandrosterone (DHEA) and its sulfate ester, DHEAS, are the most abundant steroid hormones in the humans. However, their physiological significance, their mechanisms of action and their possible roles as treatment are not fully clarified. Biological actions of DHEA(S) in the brain involve neuroprotection, neurite growth, neurogenesis and neuronal survival, apoptosis, catecholamine synthesis and secretion, as well as anti-oxidant, anti-inflammatory and antiglucocorticoid effects. In addition, DHEA affects neurosteroidogenis and endorphin synthesis/release. We also demonstrated in a model of ovariectomized rats that DHEA therapy increases proceptive behaviors, already after 1 week of treatment, affecting central function of sexual drive. In women, the analyses of clinical outcomes are far from being conclusive and many issues should still be addressed. Although DHEA preparations have been available in the market since the 1990s, there are very few definitive reports on the biological functions of this steroid. We demonstrate that 1 year DHEA administration at the dose of 10mg provided a significant improvement in comparison with vitamin D in sexual function and in frequency of sexual intercourse in early postmenopausal women. Among symptomatic women, the spectrum of symptoms responding to DHEA requires further investigation, to define the type of sexual symptoms (e.g. decreased sexual function or hypoactive sexual desire disorder) and the degree of mood/cognitive symptoms that could be responsive to hormonal treatment. In this regard, our findings are promising, although they need further exploration with a larger and more representative sample size. This article is part of a Special Issue entitled: Essential role of DHEA.
Keywords
Affect, Animals, Anxiety/metabolism, Brain/metabolism, Cognition, Cognition Disorders/metabolism, Dehydroepiandrosterone/metabolism, Dehydroepiandrosterone Sulfate/metabolism, Depression/metabolism, Female, Humans, Male, Mood Disorders/metabolism, Neurobiology, Neurotransmitter Agents/metabolism, Sexual Behavior, Brain, DHEA, DHEA treatment, DHEAS, Sexual function
Pubmed
Web of science
Create date
15/09/2023 12:24
Last modification date
27/09/2023 9:14
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