Recent Developments on the Use of Nanomaterials for the Treatment of Epilepsy.

Details

Serval ID
serval:BIB_CF0772BCD96E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Recent Developments on the Use of Nanomaterials for the Treatment of Epilepsy.
Journal
Mini reviews in medicinal chemistry
Author(s)
Pedrero S.G., Staedler D., Gerber-Lemaire S.
ISSN
1875-5607 (Electronic)
ISSN-L
1389-5575
Publication state
Published
Issued date
2022
Peer-reviewed
Oui
Volume
22
Number
11
Pages
1460-1475
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Epilepsy affects more than 40 million people worldwide, constituting one of the most debilitating disorders of the Central Nervous System (CNS). It results from an imbalance in the electrical activity of neurons, which is primarily mediated by calcium ions. In many cases, treatment with Antiepileptic Drugs (AEDs) that regulate calcium channel activity results in successful seizure control. However, AEDs frequently cause adverse effects that range in severity from minimal impairment of the CNS to death from aplastic anemia or hepatic failure. Moreover, 30% of epileptic patients show drug-resistant epilepsy and do not respond to any form of medical treatment. In this context, nanotechnology has emerged as an excellent tool to overcome AEDs limitations. Numerous nano-strategies have been proposed as therapeutics and diagnostics for epilepsy through inhibition of different calcium channel types in the brain. In addition, limited brain access of classical AEDs in patients showing refractory epilepsy could be improved through the design of targeted drug delivery nanosystems. This report presents a review of the nanocarriers developed so far that could facilitate the interaction with calcium channels in the brain and the transport of AEDs through the blood-brain-barrier, mapping out a potential future direction in the research of epilepsy treatment.
Keywords
Anticonvulsants/pharmacology, Anticonvulsants/therapeutic use, Calcium Channels, Drug Resistant Epilepsy/drug therapy, Epilepsy/drug therapy, Humans, Nanostructures/therapeutic use, Epilepsy, antiepileptic drugs, blood-brain barrier, calcium channels, central nervous system, drug delivery, nanomaterials
Pubmed
Web of science
Create date
11/01/2022 15:30
Last modification date
01/04/2023 5:51
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