Lessons learned in application driven imaging agent design for image-guided surgery.
Details
Serval ID
serval:BIB_CEF2F38719D5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Lessons learned in application driven imaging agent design for image-guided surgery.
Journal
European journal of nuclear medicine and molecular imaging
ISSN
1619-7089 (Electronic)
ISSN-L
1619-7070
Publication state
Published
Issued date
08/2024
Peer-reviewed
Oui
Volume
51
Number
10
Pages
3040-3054
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
To meet the growing demand for intraoperative molecular imaging, the development of compatible imaging agents plays a crucial role. Given the unique requirements of surgical applications compared to diagnostics and therapy, maximizing translational potential necessitates distinctive imaging agent designs. For effective surgical guidance, exogenous signatures are essential and are achievable through a diverse range of imaging labels such as (radio)isotopes, fluorescent dyes, or combinations thereof. To achieve optimal in vivo utility a balanced molecular design of the tracer as a whole is required, which ensures a harmonious effect of the imaging label with the affinity and specificity (e.g., pharmacokinetics) of a pharmacophore/targeting moiety. This review outlines common design strategies and the effects of refinements in the molecular imaging agent design on the agent's pharmacological profile. This includes the optimization of affinity, pharmacokinetics (including serum binding and target mediated background), biological clearance route, the achievable signal intensity, and the effect of dosing hereon.
Keywords
Humans, Surgery, Computer-Assisted/methods, Molecular Imaging/methods, Animals, Drug Design, Image-guided surgery, Imaging agent development, Pharmacokinetics, Receptor targeting, Tracer development molecular design
Pubmed
Web of science
Open Access
Yes
Create date
25/06/2024 9:52
Last modification date
10/08/2024 7:30