Morphological differences in Parkinson's disease with and without rest tremor.

Details

Ressource 1Request a copy Sous embargo indéterminé.
State: Public
Version: Final published version
Serval ID
serval:BIB_CEE25E2C6D01
Type
Article: article from journal or magazin.
Collection
Publications
Title
Morphological differences in Parkinson's disease with and without rest tremor.
Journal
Journal of Neurology
Author(s)
Benninger D.H., Thees S., Kollias S.S., Bassetti C.L., Waldvogel D.
ISSN
1432-1459 (Electronic)
ISSN-L
0340-5354
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
256
Number
2
Pages
256-263
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish. PDF type: ORIGINAL COMMUNICATION
Abstract
BACKGROUND: Rest tremor is a hallmark of Parkinson's disease (PD), but its pathogenesis remains incompletely understood. Nigro-striatal dopamine deficiency correlates best with bradykinesia, but not with tremor. Oscillating neurons in one or multiple localizations within the basal gangliathalamo-cortical loop may cause rest tremor, and an active contribution of the cerebellum and the cerebello-thalamo-cortical projections has been postulated.
OBJECTIVE: To compare the pattern of grey matter volume in PD patients with and without tremor to identify structural correlates of rest tremor.
METHODS: Voxel-based morphometry (VBM) of a high-resolution 3 Tesla, T1-weighted MR images, pre-processed according to an optimized protocol using SPM2, was performed in 24 patients with mild to moderate PD comparing local grey matter volume in patients with (n = 14) and without rest tremor (n = 10).
RESULTS: Grey matter volume is decreased in the right quadrangular lobe and declive of the cerebellum in PD with tremor compared to those without (PFDR < 0.05).
CONCLUSIONS: These results demonstrate for the first time morphological changes in the cerebellum in PD patients with rest tremor and highlight the involvement of the cerebellum and cerebello- thalamo-cortical circuit in the pathogenesis of parkinsonian rest tremor.
Keywords
Aged, Atrophy/etiology, Atrophy/pathology, Brain/pathology, Brain/physiopathology, Brain Mapping, Cerebellum/pathology, Cerebellum/physiopathology, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Motor Cortex/pathology, Motor Cortex/physiopathology, Neural Pathways/pathology, Neural Pathways/physiopathology, Parkinson Disease/pathology, Parkinson Disease/physiopathology, Predictive Value of Tests, Thalamus/pathology, Thalamus/physiopathology, Tremor/etiology, Tremor/pathology
Pubmed
Web of science
Create date
08/10/2012 10:36
Last modification date
20/08/2019 16:49
Usage data