Further ultrastructural evidence that spirochaetes may play a role in the aetiology of Alzheimer's disease.

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State: Public
Version: Final published version
License: All rights reserved
Serval ID
serval:BIB_CECF315AB659
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Further ultrastructural evidence that spirochaetes may play a role in the aetiology of Alzheimer's disease.
Journal
Neuroreport
Author(s)
Miklossy J., Kasas S., Janzer R.C., Ardizzoni F., Van der Loos H.
ISSN
0959-4965 (Print)
ISSN-L
0959-4965
Publication state
Published
Issued date
02/06/1994
Peer-reviewed
Oui
Volume
5
Number
10
Pages
1201-1204
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Recently it was reported that, at autopsy, in neuropathologically confirmed cases of Alzheimer's disease spirochaetes were found in blood and cerebrospinal fluid using dark-field microscopy. Moreover, the spirochaetes were isolated and cultured from brain tissue. We now show, using scanning electron microscopy and atomic force microscopy that the helically shaped microorganisms isolated and cultured from the Alzheimer brains possess axial filaments. This indicates that these microorganisms taxonomically indeed belong to the order Spirochaetales. A morphometric analysis reinforces this notion.
Keywords
Alzheimer Disease/microbiology, Brain/microbiology, Cells, Cultured, Cerebral Cortex/cytology, Cerebral Cortex/microbiology, Humans, Microscopy, Electron, Scanning, Neurons/microbiology, Neurons/ultrastructure, Spirochaetales Infections/microbiology
Pubmed
Web of science
Create date
24/01/2008 15:24
Last modification date
28/07/2020 6:21
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