Adaptation, co-evolution, and human susceptibility to HIV-1 infection
Details
Serval ID
serval:BIB_CEC98F56A5AA
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Adaptation, co-evolution, and human susceptibility to HIV-1 infection
Journal
Infection, Genetics and Evolution
ISSN
1567-1348 (Print)
Publication state
Published
Issued date
10/2005
Volume
5
Number
4
Pages
327-34
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Oct
Research Support, Non-U.S. Gov't
Review --- Old month value: Oct
Abstract
Infection with HIV-1, a retrovirus of animal origin, has reached pandemic proportions. For this the virus, characterized by rapid mutation rate, has adapted to the host immunity and to the human cellular environment. Humans are also exerting considerable pressure on HIV-1 through the use of antiretroviral agents. On the other hand, long term exposure of humans to other retroviruses and retroelements may have already shaped the human genome. Thus, despite a recent entry of HIV-1 in humans, this pathogen might be already exerting evolutionary pressure on humans, by selecting a repertoire of restriction genes and susceptibility loci.
Keywords
*Adaptation, Physiological
Animals
*Evolution
*Genetic Predisposition to Disease
HIV Infections
HIV-1/*genetics/metabolism
Humans
Pubmed
Create date
25/01/2008 15:46
Last modification date
20/08/2019 16:49