Adaptation, co-evolution, and human susceptibility to HIV-1 infection

Details

Serval ID
serval:BIB_CEC98F56A5AA
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Adaptation, co-evolution, and human susceptibility to HIV-1 infection
Journal
Infection, Genetics and Evolution
Author(s)
Telenti  A.
ISSN
1567-1348 (Print)
Publication state
Published
Issued date
10/2005
Volume
5
Number
4
Pages
327-34
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Oct
Abstract
Infection with HIV-1, a retrovirus of animal origin, has reached pandemic proportions. For this the virus, characterized by rapid mutation rate, has adapted to the host immunity and to the human cellular environment. Humans are also exerting considerable pressure on HIV-1 through the use of antiretroviral agents. On the other hand, long term exposure of humans to other retroviruses and retroelements may have already shaped the human genome. Thus, despite a recent entry of HIV-1 in humans, this pathogen might be already exerting evolutionary pressure on humans, by selecting a repertoire of restriction genes and susceptibility loci.
Keywords
*Adaptation, Physiological Animals *Evolution *Genetic Predisposition to Disease HIV Infections HIV-1/*genetics/metabolism Humans
Pubmed
Create date
25/01/2008 14:46
Last modification date
20/08/2019 15:49
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