Microbiome, Immunosenescence, and Chronic Kidney Disease.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_CEB61B5A05D1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Microbiome, Immunosenescence, and Chronic Kidney Disease.
Journal
Frontiers in medicine
Author(s)
Stavropoulou E., Kantartzi K., Tsigalou C., Aftzoglou K., Voidarou C., Konstantinidis T., Chifiriuc M.C., Thodis E., Bezirtzoglou E.
ISSN
2296-858X (Print)
ISSN-L
2296-858X
Publication state
Published
Issued date
2021
Peer-reviewed
Oui
Volume
8
Pages
661203
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
The gut microbiome is known as an important predictive tool for perceiving characteristic shifts in disease states. Multiple renal diseases and pathologies seem to be associated with gut dysbiosis which directly affects host homeostasis. The gastrointestinal-kidney dialogue confers interesting information about the pathogenesis of multiple kidney diseases. Moreover, aging is followed by specific shifts in the human microbiome, and gradual elimination of physiological functions predisposes the microbiome to inflammaging, sarcopenia, and disease. Aging is characterized by a microbiota with an abundance of disease-associated pathobionts. Multiple factors such as the immune system, environment, medication, diet, and genetic endowment are involved in determining the age of the microbiome in health and disease. Our present review promotes recently acquired knowledge and is expected to inspire researchers to advance studies and investigations on the involved pathways of the gut microbiota and kidney axis.
Keywords
ageing, chronic kidney disease, gut, gut-kidney axis, immunosenescence, kidney, microbiome, microbiota
Pubmed
Web of science
Open Access
Yes
Create date
23/05/2024 11:38
Last modification date
08/08/2024 7:40
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