Cholangiolocellular carcinoma: an innocent-looking malignant liver tumor mimicking ductular reaction.

Details

Serval ID
serval:BIB_CE84CE463EA3
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Cholangiolocellular carcinoma: an innocent-looking malignant liver tumor mimicking ductular reaction.
Journal
Seminars in Liver Disease
Author(s)
Sempoux C., Fan C., Singh P., Obeidat K., Roayaie S., Schwartz M., Fiel M.I., Thung S.N.
ISSN
1098-8971 (Electronic)
ISSN-L
0272-8087
Publication state
Published
Issued date
2011
Volume
31
Number
1
Pages
104-110
Language
english
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
The authors present an interesting case of a 60-year-old man who underwent right hepatectomy for a diagnosis of hepatocellular carcinoma (HCC) on a background of noncirrhotic chronic hepatitis C. Pathologic examination confirmed the presence of HCC near the porta hepatis, which invaded the right portal vein branch. In addition, a well-demarcated 13.5 × 7.8 × 4.0 cm yellow and firm area upstream of the HCC was noted. This yellow area corresponded to a tumoral ductular proliferation, which cytologically was extremely bland, but invaded portal tracts and the adjacent liver parenchyma. This tumoral proliferation mimicked ductular reaction, except that it had more anastomosing structures and was associated with abundant hyalinized fibrotic stroma. Cytologically, the tumor cells had round to oval nuclei with fine chromatin, indistinct nucleoli, and scant cytoplasm. They exhibited immunohistochemical features of hepatic progenitor cells, i.e., expressing CK7, CK19, and N-CAM; and their malignancy was supported by the p53 and Ki67 immunoreactivity. The authors concluded that the patient had cholangiolocellular carcinoma with an aggressive hepatocellular carcinoma component. Cholangiolocellular carcinoma has been reported to be associated with chronic hepatitis C viral infection and to derive from hepatic progenitor cells, which explains why hepatocellular carcinoma and/or cholangiocarcinoma component may be present.
Keywords
Bile Duct Neoplasms/chemistry, Bile Duct Neoplasms/diagnosis, Bile Ducts, Intrahepatic/chemistry, Bile Ducts, Intrahepatic/pathology, Biopsy, Carcinoma, Hepatocellular/chemistry, Carcinoma, Hepatocellular/diagnosis, Cholangiocarcinoma/chemistry, Cholangiocarcinoma/diagnosis, Diagnosis, Differential, Hepatectomy, Hepatitis C, Chronic/complications, Humans, Immunohistochemistry, Liver Neoplasms/chemistry, Liver Neoplasms/diagnosis, Male, Middle Aged, Mixed Tumor, Malignant/chemistry, Mixed Tumor, Malignant/diagnosis, Predictive Value of Tests, Tomography, X-Ray Computed, Tumor Markers, Biological/analysis
Pubmed
Web of science
Create date
19/01/2015 10:49
Last modification date
20/08/2019 15:49
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