Pneumocystis jirovecii genotype associated with increased death rate of HIV-infected patients with pneumonia.

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State: Public
Version: author
Serval ID
serval:BIB_CE80293E8EF4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Pneumocystis jirovecii genotype associated with increased death rate of HIV-infected patients with pneumonia.
Journal
Emerging Infectious Diseases
Author(s)
Rabodonirina M., Vaillant L., Taffé P., Nahimana A., Gillibert R.P., Vanhems P., Hauser P.M.
ISSN
1080-6059 (Electronic)
ISSN-L
1080-6040
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
19
Number
1
Pages
21-28
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
Pneumocystis jirovecii dihydropteroate synthase (DHPS) mutations have been associated with failure of sulfa prophylaxis; their effect on the outcome of patients with P. jirovecii pneumonia (PCP) remains controversial. P. jirovecii DHPS polymorphisms and genotypes were identified in 112 cases of PCP in 110 HIV-infected patients by using PCR single-strand conformation polymorphism. Of the 110 patients observed, 21 died; 18 of those deaths were attributed to PCP. Thirty-three percent of the PCP cases involved a P. jirovecii strain that had 1 or both DHPS mutations. The presence or absence of DHPS mutations had no effect on the PCP mortality rate within 1 month, whereas P.jirovecii type 7 and mechanical ventilation at PCP diagnosis were associated with an increased risk of death caused by PCP. Mechanical ventilation at PCP diagnosis was also associated with an increased risk of sulfa treatment failure at 5 days.
Pubmed
Web of science
Open Access
Yes
Create date
27/12/2012 12:25
Last modification date
20/08/2019 16:49
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