Diverse cellular and molecular modes of axon degeneration.

Details

Serval ID
serval:BIB_CE71BCC54D24
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Diverse cellular and molecular modes of axon degeneration.
Journal
Trends in cell biology
Author(s)
Neukomm L.J., Freeman M.R.
ISSN
1879-3088 (Electronic)
ISSN-L
0962-8924
Publication state
Published
Issued date
09/2014
Peer-reviewed
Oui
Volume
24
Number
9
Pages
515-523
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
The elimination of large portions of axons is a widespread event in the developing and diseased nervous system. Subsets of axons are selectively destroyed to help fine-tune neural circuit connectivity during development. Axonal degeneration is also an early feature of nearly all neurodegenerative diseases, occurs after most neural injuries, and is a primary driver of functional impairment in patients. In this review we discuss the diversity of cellular mechanisms by which axons degenerate. Initial molecular characterization highlights some similarities in their execution but also argues that unique genetic programs modulate each mode of degeneration. Defining these pathways rigorously will provide new targets for therapeutic intervention after neural injury or in neurodegenerative disease.
Keywords
Axons/metabolism, Axons/pathology, Humans, Nerve Degeneration/pathology, Nervous System/metabolism, Nervous System/pathology, Neurodegenerative Diseases/metabolism, Neurodegenerative Diseases/pathology, Neuroglia/metabolism, Neuroglia/pathology, Wallerian degeneration, axon degeneration, axon retraction, axosome shedding, glia, pruning
Pubmed
Web of science
Create date
08/12/2023 10:45
Last modification date
09/12/2023 8:03
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