A single dose of intravenous esomeprazole decreases gastric secretion in healthy volunteers.
Details
Serval ID
serval:BIB_CE3BABBBBB6F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A single dose of intravenous esomeprazole decreases gastric secretion in healthy volunteers.
Journal
Alimentary Pharmacology & Therapeutics
ISSN
1365-2036[electronic]
Publication state
Published
Issued date
2009
Volume
30
Number
10
Pages
1022-1029
Language
english
Abstract
BACKGROUND: Data suggest that esomeprazole decreases gastric secretion. AIMS: To assess the effect of a single i.v. esomeprazole dose on gastric secretion volume 3 h after drug administration, as a primary endpoint, and to evaluate, as secondary endpoints, the reduction 1 and 5 h after dosing; time when the gastric pH was <2.5 and esomeprazole's safety. METHODS: In all, 23 healthy Helicobacter pylori-negative volunteers (10 men, 13 women, mean age 28.2 +/- 6) participated in this single-centre, randomized, double-blind, placebo-controlled, 2-way, single-dose cross-over study. In different sessions, volunteers received i.v. either esomeprazole 40 mg or placebo. An inserted double-lumen nasogastric tube perfused and aspirated gastric liquid. Mechanical fractioned aspiration measured secretion volume; aliquot spectrophotometry assessed gastric secretion volume lost to the duodenum. RESULTS: Three hours post-i.v. esomeprazole, average gastric secretion decreased by 77.6% (vs. baseline) compared to placebo. Values 1 and 5 h after dosing were 73.5% and 74.5%. Five hours after esomeprazole, the gastric pH was <2.5 3.9% of the time and 73.3% after placebo (P < 0.002). Esomeprazole was well-tolerated. No serious adverse events occurred. CONCLUSIONS: Intravenous esomeprazole decreases gastric secretions. The potential clinical impact in averting bronchoaspiration during anaesthesia induction and in intensive care patients should be investigated in further studies.
Keywords
Pantoprazole 40 Mg, Proton Pump Inhibitors, Lansoprazole 30 Mg, Intragastric Acid Control, Elective-Surgery, Omeprazole, Ranitidine, Adults, Volume, Ph
Pubmed
Web of science
Open Access
Yes
Create date
05/11/2009 9:24
Last modification date
20/08/2019 16:48