Diversite de l'atteinte neuromusculaire de 47 patients infectes par le virus de l'immunodeficience humaine. [Range of neuromuscular involvement in 47 patients infected with the human immunodeficiency virus]

Details

Serval ID
serval:BIB_CE2F15528BF3
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Diversite de l'atteinte neuromusculaire de 47 patients infectes par le virus de l'immunodeficience humaine. [Range of neuromuscular involvement in 47 patients infected with the human immunodeficiency virus]
Journal
Schweizerische Medizinische Wochenschrift
Author(s)
Ghika-Schmid  F., Kuntzer  T., Chave  J. P., Miklossy  J., Regli  F.
ISSN
0036-7672 (Print)
Publication state
Published
Issued date
05/1994
Peer-reviewed
Oui
Volume
124
Number
19
Pages
791-800
Notes
English Abstract Journal Article Review --- Old month value: May 14
Abstract
Over a 30 month period, 47 out of 749 patients infected with the human immunodeficiency virus had various neuromuscular symptoms. Based on clinical and electrophysiological data, 47% had distal symmetric polyneuropathy, 11% chronic inflammatory demyelinating polyneuropathy (CIDP), 8.5% toxic neuropathy related to 2-3-dideoxyinosine (DDI), 8.5% cranial neuropathy, 8.5% mononeuropathy multiplex or isolated focal neuropathy, 8.5% progressive lumbosacral polyradiculopathy, and 8.5% myopathy. Half of the patients exhibited previous or concomitant signs of central nervous system involvement and 18 patients died during the study period. CIDP and cranial neuropathies usually appeared early in the course of the disease and consequently showed neurological improvement. Nerve conduction studies of DDI related toxic neuropathies showed distal axono-myelinic sensitivo-motor neuropathy, differing from CIDP by the absence of a conduction block. Distal symmetric polyneuropathies, frequent in the advanced systemic illness, do not systematically require an extended workup, but more unusual peripheral neuropathies which might be treatable necessitate further investigations (electromyography, radiology, serological blood tests; protein chemistry and routine workup of the cerebrospinal fluid). For example, progressive lumbosacral polyradiculopathies responded to early treatment, with a better outcome in one case of herpetic origin than in another case due to cytomegalovirus infection. Our observations suggest that myopathies in HIV infected patients should first be tackled by temporary interruption of virostatic medication, followed by muscle biopsy if the symptoms persist.
Keywords
AIDS Dementia Complex/*complications Adult Aged Central Nervous System Diseases/chemically induced/complications Cranial Nerve Diseases/complications Didanosine/adverse effects Female HIV Infections/*complications Humans Male Middle Aged Neural Conduction Neuromuscular Diseases/chemically induced/*complications/diagnosis Peripheral Nervous System Diseases/complications
Pubmed
Web of science
Create date
25/01/2008 12:44
Last modification date
20/08/2019 15:48
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