The Genetics of Inflammatory Bowel Disease.
Details
Download: 37847439_BIB_CE26F5D1F449.pdf (732.63 [Ko])
State: Public
Version: Final published version
License: CC BY-NC 4.0
State: Public
Version: Final published version
License: CC BY-NC 4.0
Serval ID
serval:BIB_CE26F5D1F449
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The Genetics of Inflammatory Bowel Disease.
Journal
Molecular diagnosis & therapy
ISSN
1179-2000 (Electronic)
ISSN-L
1177-1062
Publication state
Published
Issued date
01/2024
Peer-reviewed
Oui
Volume
28
Number
1
Pages
27-35
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
The genetic background of inflammatory bowel disease, both Crohn's disease and ulcerative colitis, has been known for more than 2 decades. In the last 20 years, genome-wide association studies have dramatically increased our knowledge on the genetics of inflammatory bowel disease with more than 200 risk genes having been identified. Paralleling this increasing knowledge, the armamentarium of inflammatory bowel disease medications has been growing constantly. With more available therapeutic options, treatment decisions become more complex, with still many patients experiencing a debilitating disease course and a loss of response to treatment over time. With a better understanding of the disease, more effective personalized treatment strategies are looming on the horizon. Genotyping has long been considered a strategy for treatment decisions, such as the detection of thiopurine S-methyltransferase and nudix hydrolase 15 polymorphisms before the initiation of azathioprine. However, although many risk genes have been identified in inflammatory bowel disease, a substantial impact of genetic risk assessment on therapeutic strategies and disease outcome is still missing. In this review, we discuss the genetic background of inflammatory bowel disease, with a particular focus on the latest advances in the field and their potential impact on management decisions.
Keywords
Humans, Genome-Wide Association Study, Inflammatory Bowel Diseases/diagnosis, Inflammatory Bowel Diseases/genetics, Colitis, Ulcerative/drug therapy, Colitis, Ulcerative/genetics, Colitis, Ulcerative/diagnosis, Crohn Disease/diagnosis, Crohn Disease/drug therapy, Crohn Disease/genetics, Azathioprine/therapeutic use
Pubmed
Web of science
Open Access
Yes
Create date
06/11/2023 14:46
Last modification date
09/08/2024 16:06