A multi-omics digital research object for the genetics of sleep regulation.

Details

Serval ID
serval:BIB_CE11322FA283
Type
Article: article from journal or magazin.
Collection
Publications
Title
A multi-omics digital research object for the genetics of sleep regulation.
Journal
Scientific data
Author(s)
Jan M., Gobet N., Diessler S., Franken P., Xenarios I.
ISSN
2052-4463 (Electronic)
ISSN-L
2052-4463
Publication state
Published
Issued date
31/10/2019
Peer-reviewed
Oui
Volume
6
Number
1
Pages
258
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
With the aim to uncover the molecular pathways underlying the regulation of sleep, we recently assembled an extensive and comprehensive systems genetics dataset interrogating a genetic reference population of mice at the levels of the genome, the brain and liver transcriptomes, the plasma metabolome, and the sleep-wake phenome. To facilitate a meaningful and efficient re-use of this public resource by others we designed, describe in detail, and made available a Digital Research Object (DRO), embedding data, documentation, and analytics. We present and discuss both the advantages and limitations of our multi-modal resource and analytic pipeline. The reproducibility of the results was tested by a bioinformatician not implicated in the original project and the robustness of results was assessed by re-annotating genetic and transcriptome data from the mm9 to the mm10 mouse genome assembly.
Pubmed
Web of science
Open Access
Yes
Create date
02/11/2019 23:47
Last modification date
17/01/2020 7:26
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