Analyse critique des résultats de biopsies musculaires et de la méthodologie utilisée dans 889 cas d'affections neuromusculaires [Critical analysis of the results of muscle biopsies and of the methods used in 889 cases of neuromuscular disorders]

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State: Public
Version: Final published version
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Serval ID
serval:BIB_CDFC76F913CF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Analyse critique des résultats de biopsies musculaires et de la méthodologie utilisée dans 889 cas d'affections neuromusculaires [Critical analysis of the results of muscle biopsies and of the methods used in 889 cases of neuromuscular disorders]
Journal
Schweizerische Rundschau Für Medizin Praxis = Revue Suisse De Médecine Praxis
Author(s)
Deruaz J.P., Janzer R.C.
ISSN
1013-2058
Publication state
Published
Issued date
1994
Peer-reviewed
Oui
Volume
83
Number
4
Pages
101-105
Language
french
Abstract
The contribution of muscle biopsies to the diagnosis of neuromuscular disorders and the indications of various methods of examination are investigated by analysis of 889 biopsies from patients suffering from myopathic and/or neurogenic disorders. Histo-enzymatic studies performed on frozen material as well as immunohistochemistry and electron microscopy allowed to provide specific diagnoses in all the neurogenic disorders (polyneuropathies and motor neuron diseases), whereas one third of myopathies remained uncertain. Confrontation of neuropathological data with the clinical indications for histological investigations shows that muscle biopsies reveal the diagnosis in 25% of the cases (mainly in congenital and metabolic myopathies) and confirm and/or complete the clinical diagnosis in 50%. In the remaining cases with non specific abnormalities neuropathological investigations may help the clinician by excluding well defined neuromuscular disorders. Analysis of performed studies and results of investigations show the contribution and specificity of each method for the diagnosis. Statistical evaluation of this series indicates that cryostat sectioning for histo- and immunochemical and electron microscopy increases the rate of diagnoses of neuromuscular diseases: full investigation was necessary for the diagnosis in 30% of the cases. The interpretation of the wide range of pathological reactions in muscles requires a close cooperation with the clinician.
Keywords
Adolescent, Adult, Aged, Aged, 80 and over, Biopsy/methods, Child, Child, Preschool, Female, Histological Techniques, Humans, Immunoenzyme Techniques, Immunohistochemistry/methods, Infant, Male, Microscopy, Electron, Middle Aged, Muscles/pathology, Muscles/ultrastructure, Neuromuscular Diseases/diagnosis, Neuromuscular Diseases/pathology
Pubmed
Create date
19/10/2010 10:40
Last modification date
14/07/2020 6:21
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