Glucose transporter gene expression in early mouse embryos.

Details

Serval ID
serval:BIB_CDF3B32A44C8
Type
Article: article from journal or magazin.
Collection
Publications
Title
Glucose transporter gene expression in early mouse embryos.
Journal
Development
Author(s)
Hogan A., Heyner S., Charron M.J., Copeland N.G., Gilbert D.J., Jenkins N.A., Thorens B., Schultz G.A.
ISSN
0950-1991[print], 0950-1991[linking]
Publication state
Published
Issued date
09/1991
Volume
113
Number
1
Pages
363-372
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. Publication Status: ppublish
Abstract
The glucose transporter (GLUT) isoforms responsible for glucose uptake in early mouse embryos have been identified. GLUT 1, the isoform present in nearly every tissue examined including adult brain and erythrocytes, is expressed throughout preimplantation development. GLUT 2, which is normally present in adult liver, kidney, intestine and pancreatic beta cells is expressed from the 8-cell stage onward. GLUT 4, an insulin-recruitable isoform, which is expressed in adult fat and muscle, is not expressed at any stage of preimplantation development or in early postimplantation stage embryos. Genetic mapping studies of glucose transporters in the mouse show that Glut-1 is located on chromosome 4, Glut-2 on chromosome 3, Glut-3 on chromosome 6, and Glut-4 on chromosome 11.
Keywords
Amino Acid Sequence, Animals, Base Sequence, Chromosome Mapping, Cloning, Molecular, Diabetes Mellitus/genetics, Embryo, Mammalian/physiology, Fluorescent Antibody Technique, Gene Expression/physiology, Linkage (Genetics)/genetics, Mice, Mice, Inbred Strains, Molecular Sequence Data, Monosaccharide Transport Proteins/genetics, Oocytes/physiology, Polymerase Chain Reaction, Rats, Sequence Homology, Nucleic Acid
Pubmed
Web of science
Create date
24/01/2008 13:41
Last modification date
20/08/2019 15:48
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