Use of NSAIDS compared to paracetamol as potential risk factors for asthma

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State: Public
Version: author
Serval ID
serval:BIB_CDD6142332D9
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Use of NSAIDS compared to paracetamol as potential risk factors for asthma
Title of the conference
Joint annual meeting of the Swiss Society for Pediatrics, Swiss Society of Pediatric Pneumology
Author(s)
Marquis Adine, Strippoli Marie-Pierre F., Rebholz Cornelia E., Spycher Ben D., Von Der Weid Nicolas, Kuehni Claudia E.
Address
Crans Montana, Switzerland, June 17-18, 2010
ISBN
1424-7860
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
140
Series
Swiss Medical Weekly
Pages
31S
Language
english
Notes
Meeting Abstract
Abstract
Introduction: Use of paracetamol has been associated with an
increased risk of asthma in several epidemiological studies. In
contrast, it has been suggested that non-steroidal anti-inflammatory
drugs (NSAIDs) might be protective (Kanabar, Clin Ther 2007), but
data relating to these drugs are scarce.
Methods: Prevalence of asthma and intake of analgesics in the past
2 years were assessed by questionnaire in 2008 in young adults
(≥;16 years) diagnosed with cancer between 1976 and 2003 (Swiss
Childhood Cancer Survivor Study). In a multivariate logistic regression
we analysed the association between asthma and intake of
paracetamol only, NSAIDs only or their combination, adjusting for age,
sex, cancer diagnosis, cancer therapy and time since diagnosis.
Results: Of the 1293 participants (response rate 68%), 83 (6%)
reported asthma and 845 (65%) intake of analgesics in the past
2 years. Of these, 257 (29%) took paracetamol only, 224 (25%)
NSAIDs only, 312 (35%) a combination of both and 52 (6%) other
analgesics. Adjusted Odds ratios for asthma were 2.2 (95% CI 1.0-4.7;
p = 0.04), 1.9 (0.9-4.3; p = 0.12) and 2.9 (1.4-6.1; p <0.01) in those
using paracetamol only, NSAIDs only or their combination respectively.
Conclusion: These cross-sectional data in a selected population do
not support a protective effect of NSAIDs against asthma, neither
taken alone nor in combination with paracetamol. All analgesics were
positively associated with reported asthma episodes in the past
two years. This can be explained by reverse causation, with intake
of analgesics being a result rather than a cause of asthma events.
Randomised controlled trials in unselected populations are needed
to clarify the direction of causation.
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Create date
08/09/2010 15:23
Last modification date
20/08/2019 16:48
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