Sensitive and selective determination of methylenedioxylated amphetamines by high-performance liquid chromatography with fluorimetric detection.

Details

Serval ID
serval:BIB_CDD4AD392292
Type
Article: article from journal or magazin.
Collection
Publications
Title
Sensitive and selective determination of methylenedioxylated amphetamines by high-performance liquid chromatography with fluorimetric detection.
Journal
Journal of chromatography. A
Author(s)
Sadeghipour F., Veuthey J.L.
ISSN
0021-9673 (Print)
ISSN-L
0021-9673
Publication state
Published
Issued date
07/11/1997
Peer-reviewed
Oui
Volume
787
Number
1-2
Pages
137-143
Language
english
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Abstract
A rapid, sensitive and selective liquid chromatographic method with fluorimetric detection was developed for the separation and quantification of four methylenedioxylated amphetamines without interference of other drugs of abuse and common substances found in illicit tablets. The method was validated by examining linearity, precision and accuracy as well as detection and quantification limits. Methylenedioxylated amphetamines were quantified in eight tablets from illicit drug seizures and results were quantitatively compared to HPLC-UV analyses. To demonstrate the better sensitivity of the fluorimetric detection, methylenedioxylated amphetamines were analyzed in serum after a liquid-liquid extraction procedure and results were also compared to HPLC-UV analyses.
Keywords
3,4-Methylenedioxyamphetamine/analogs & derivatives, 3,4-Methylenedioxyamphetamine/blood, Amphetamines/blood, Chromatography, High Pressure Liquid, Humans, N-Methyl-3,4-methylenedioxyamphetamine/blood, Reproducibility of Results, Sensitivity and Specificity, Spectrometry, Fluorescence, Spectrophotometry, Ultraviolet, Substance Abuse Detection/methods, Tablets
Pubmed
Web of science
Create date
27/02/2019 10:53
Last modification date
20/08/2019 15:48
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