Extracellular magnesium depletion in pediatric patients with insulin-dependent diabetes mellitus

Details

Serval ID
serval:BIB_CDB70CD40192
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Extracellular magnesium depletion in pediatric patients with insulin-dependent diabetes mellitus
Journal
Mineral and Electrolyte Metabolism
Author(s)
Husmann  M. J., Fuchs  P., Truttmann  A. C., Laux-End  R., Mullis  P. E., Peheim  E., Bianchetti  M. G.
ISSN
0378-0392 (Print)
Publication state
Published
Issued date
1997
Volume
23
Number
2
Pages
121-4
Notes
Journal Article
Abstract
It is unclear whether insulin-dependent diabetes mellitus is a state of magnesium depletion. This is a relevant question, since magnesium deficiency has been implicated in the pathogenesis of diseases that develop to an increased extent into diabetes mellitus. Total plasma magnesium was not statistically different in 76 pediatric patients with insulin-dependent diabetes mellitus (0.77 [0.73-0.81] mmol/l; median and interquartile range), 59 healthy adults (0.80 [0.77-0.83] mmol/l) and 19 healthy children (0.80 [0.78-0.83] mmol/l). In contrast, plasma ionized magnesium, the most interesting form with respect to physiological and biological properties, was significantly lower in diabetic patients (0.50 [0.48-0.53] mmol/l) when compared with healthy adults (0.53 [0.50-0.56] mmol/l; p < 0.01) and healthy children (0.54 [0.51-0.56] mmol/l; p < 0.02). Our report confirms recent findings of reduced circulating ionized magnesium but normal circulating total magnesium in adults with non-insulin-dependent diabetes mellitus.
Keywords
Adolescent Adult Calcium/blood Cations Child Child, Preschool Diabetes Mellitus, Type 1/blood/*complications Extracellular Space/*metabolism Female Humans Hydrogen-Ion Concentration Magnesium/blood Magnesium Deficiency/*etiology Male Reference Values
Pubmed
Web of science
Create date
28/01/2008 13:50
Last modification date
20/08/2019 15:48
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