Episodic memory in mild cognitive impairment inversely correlates with the global modularity of the cerebral blood flow network.

Details

Serval ID
serval:BIB_CD97DBBFE69A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Episodic memory in mild cognitive impairment inversely correlates with the global modularity of the cerebral blood flow network.
Journal
Psychiatry research. Neuroimaging
Author(s)
Sánchez-Catasús C.A., Willemsen A., Boellaard R., Juarez-Orozco L.E., Samper-Noa J., Aguila-Ruiz A., De Deyn P.P., Dierckx R., Medina Y.I., Melie-Garcia L.
ISSN
1872-7506 (Electronic)
ISSN-L
0925-4927
Publication state
Published
Issued date
30/12/2018
Peer-reviewed
Oui
Volume
282
Pages
73-81
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Cerebral blood flow (CBF) SPECT is an interesting methodology to study brain connectivity in mild cognitive impairment (MCI) since it is accessible worldwide and can be used as a biomarker of neuronal injury in MCI. In CBF SPECT, connectivity is grounded in group-based correlation networks. Therefore, topological metrics derived from the CBF correlation network cannot be used to support diagnosis and prognosis individually. However, methods to extract the individual patient contribution to topological metrics of group-based correlation networks were developed although not yet applied to MCI patients. Here, we investigate whether the episodic memory of 24 amnestic MCI patients correlates with individual patient contributions to topological metrics of the CBF correlation network. We first compared topological metrics of the MCI group network with the network corresponding to 26 controls. Metrics that showed significant differences were then used for the individual patient contribution analysis. We found that the global network modularity was increased while global efficiency decreased in the MCI network compared to the control. Most importantly, we found that episodic memory inversely correlates with the patient contribution to the global network modularity, which highlights the potential of this approach to develop a CBF connectivity-based biomarker at the individual level.
Keywords
Aged, Brain/blood supply, Brain/diagnostic imaging, Brain/physiopathology, Brain Mapping/methods, Cerebrovascular Circulation/physiology, Cognitive Dysfunction/diagnostic imaging, Cognitive Dysfunction/physiopathology, Female, Humans, Male, Memory, Episodic, Middle Aged, Tomography, Emission-Computed, Single-Photon/methods, Brain connectivity, Cerebral blood flow, Episodic memory, Global network modularity, Mild cognitive impairment, Single-photon emission computed tomography (SPECT)
Pubmed
Web of science
Create date
19/11/2018 13:26
Last modification date
20/08/2019 15:48
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