Renal Resistive Index Is Associated With Inactive Matrix Gla (γ-Carboxyglutamate) Protein in an Adult Population-Based Study.

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State: Public
Version: author
License: CC BY 4.0
Serval ID
serval:BIB_CD902C423491
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Renal Resistive Index Is Associated With Inactive Matrix Gla (γ-Carboxyglutamate) Protein in an Adult Population-Based Study.
Journal
Journal of the American Heart Association
Author(s)
Jaques D.A., Pivin E., Pruijm M., Ackermann D., Guessous I., Ehret G., Wei F.F., Staessen J.A., Pechère-Bertschi A., Vermeer C., Vogt B., Burnier M., Martin P.Y., Bochud M., Ponte B.
ISSN
2047-9980 (Electronic)
ISSN-L
2047-9980
Publication state
Published
Issued date
17/09/2019
Peer-reviewed
Oui
Volume
8
Number
18
Pages
e013558
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Background Increased renal resistive index (RRI) has been associated with target organ damage as well as renal and cardiovascular outcomes. Matrix Gla (γ-carboxyglutamate) protein (MGP) is a strong inhibitor of soft tissue calcification. Its inactive form (dephospho-uncarboxylated MGP [dp-ucMGP]) has been associated with vascular stiffness, cardiovascular outcomes, and mortality. In this study, we hypothesized that high levels of dp-ucMGP were associated with increased RRI. Methods and Results We recruited participants via a multicenter family-based cross-sectional study in Switzerland. Levels of dp-ucMGP were measured in plasma by sandwich ELISA. RRI was measured by Doppler ultrasound in 3 segmental arteries in both kidneys. We used mixed regression models to assess the relationship between dp-ucMGP and RRI. We adjusted for common determinants of RRI as well as renal function and cardiovascular risk factors. We included 1006 participants in our analyses: 526 women and 480 men. Mean values were 0.44±0.20 nmol/L for dp-ucMGP and 64±5% for RRI. After multivariable adjustment, dp-ucMGP was positively associated with RRI (P=0.001). In subgroup analysis by age tertiles, this association was not significant in the youngest age group (<38 years; P=0.62), whereas it was significant in older age groups (38-55 and >55 years; P=0.016 and P<0.001, respectively). Conclusions Levels of dp-ucMGP are positively and independently associated with RRI after adjustment for common determinants of RRI, cardiovascular risk factors, and renal function. The stronger association among older adults is probably due, in part, to age-related arterial stiffness. RRI thus seems to reflect the global atherosclerotic burden in a general adult population.
Keywords
atherosclerosis, matrix Gla (γ‐carboxyglutamate) protein, pulse pressure, pulse wave velocity, renal physiology, renal resistive index, vascular stiffness 2047-9980 (Electronic), vascular stiffness
Pubmed
Web of science
Open Access
Yes
Create date
23/09/2019 14:42
Last modification date
20/01/2021 7:26
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