Concentrations of azithromycin in tonsilar and/or adenoid tissue from paediatric patients.

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Ressource 1Download: serval:BIB_CD488D5D3280.P001 (347.37 [Ko])
State: Public
Version: author
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_CD488D5D3280
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Concentrations of azithromycin in tonsilar and/or adenoid tissue from paediatric patients.
Journal
Journal of Antimicrobial Chemotherapy
Author(s)
Vaudaux B.P., Cherpillod J., Dayer P.
ISSN
0305-7453 (Print)
ISSN-L
0305-7453
Publication state
Published
Issued date
06/1996
Peer-reviewed
Oui
Volume
37 Suppl C
Pages
45-51
Language
english
Notes
Publication types: Clinical Trial ; Journal Article
Publication Status: ppublish
Abstract
Azithromycin levels in tonsillar and/or adenoid tissue were determined in children (1.6-7.5 years old) who were scheduled for surgical removal of their tonsils and/or adenoids. The children received azithromycin oral suspension 10 mg/kg once daily for 3 days. Tissue samples were obtained during surgery 1 (n = 4), 2 (n = 5), 4 (n = 6), or 8 (n = 5) days after the last dose of azithromycin. Serum samples were also obtained from four children in each of these groups at the time of surgery. Mean tissue concentrations of azithromycin were 10.33 +/- 3.01, 7.21 +/- 4.04, 9.30 +/- 3.74 and 1.49 +/- 0.48 mg/kg, respectively, 1, 2, 4 and 8 days after the last dose. At the corresponding times, serum concentrations were markedly lower: 47.25 +/- 19. 19, 14.00 +/- 8.45, 8.00 +/- 2.16 and < 4 micrograms/L, respectively. The mean tissue:serum concentration ratios were, 227 +/- 54, 547 +/- 184 and 956 +/- 355, respectively, 1, 2 and 4 days after treatment. No adverse events attributable to azithromycin were observed in any of the 23 children who had received at least one dose of azithromycin. The study shows that levels of azithromycin in tonsillar and adenoid tissue were consistently higher than in serum and remained elevated up to 8 days after the end of dosing, supporting the use of a short-course (3-day), once-daily regimen of azithromycin in the treatment of upper respiratory tract infections.
Keywords
Adenoids/metabolism, Anti-Bacterial Agents/administration & dosage, Anti-Bacterial Agents/adverse effects, Azithromycin/administration & dosage, Azithromycin/adverse effects, Child, Child, Preschool, Female, Humans, Male, Palatine Tonsil/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 11:33
Last modification date
25/09/2019 7:10
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