Host genome influences on susceptibility to HIV-1

Details

Serval ID
serval:BIB_CD381AEA66B2
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Host genome influences on susceptibility to HIV-1
Title of the conference
Frontiers of Retrovirology: Complex retroviruses, retroelements and their hosts
Author(s)
Telenti A.
Address
Montpellier, France. 21-23 SEP 2009
ISBN
1742-4690
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
6
Series
Retrovirology
Pages
-
Language
english
Notes
Meeting Abstract
Abstract
In vitro and in vivo analyses identified a significant component of heritability in cellular or host susceptibility to HIV-1. The bases for susceptibility can be traced to genetic differences (inter-species) resulting from evolutionary adaptation to exogenous (and endogenous) retroviral infections, and to intra-species and inter-individual (human) differences associated with genetic variation. We have completed large scale evolutionary analysis of genes involved in HIV life cycle and pathogenesis, as well as participating and conducting genome-wide association studies, linkage analysis, and transcriptome analysis. These studies allowed a better understanding of the influence of common human variants in HIV-1 susceptibility and define a number of experimental challenges in the filed: understanding of the role of rare and private mutations in susceptibility, and the development of better tools for the integration of data from large-scale studies.
Web of science
Open Access
Yes
Create date
03/11/2009 10:05
Last modification date
20/08/2019 15:47
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