Bone marrow involvement by disseminated toxoplasmosis in acquired immunodeficiency syndrome: the value of bone marrow trephine biopsy and immunohistochemistry for the diagnosis.

Details

Serval ID
serval:BIB_CCF93349FC60
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Bone marrow involvement by disseminated toxoplasmosis in acquired immunodeficiency syndrome: the value of bone marrow trephine biopsy and immunohistochemistry for the diagnosis.
Journal
Human Pathology
Author(s)
Brouland J.P., Audouin J., Hofman P., Le Tourneau A., Basset D., Rio B., Zittoun R., Diebold J.
ISSN
0046-8177 (Print)
ISSN-L
0046-8177
Publication state
Published
Issued date
1996
Peer-reviewed
Oui
Volume
27
Number
3
Pages
302-306
Language
english
Notes
Publication types: Case Reports ; Journal ArticlePublication Status: ppublish
Abstract
A bone marrow biopsy was performed on four patients with acquired immune deficiency syndrome (AIDS) for a long-running course fever of unknown origin associated with a recent pancytopenia. In the four cases, striking histological similarities, such as interstitial edema, foci of necrosis and only few scattered or clustered histiocytes, were found. Near or in the foci of necrosis, free forms, and pseudocysts of Toxoplasma gondii were observed not only in the cytoplasm of macrophages and of some granulocytes, but also within megakaryocytes. No sign of other parasitic, bacterial, or fungus infection has been found. The diagnosis was confirmed by immunohistochemistry in the four cases and ultrastructural examination in one case. This case study stresses the importance of bone marrow histological changes for the diagnosis of severe toxoplasmosis in AIDS patients and particularly the localization of T gondii within the cytoplasm of megakaryocytes.
Keywords
AIDS-Related Opportunistic Infections/diagnosis, AIDS-Related Opportunistic Infections/parasitology, Adult, Animals, Biopsy, Bone Marrow/parasitology, Bone Marrow/pathology, Bone Marrow Diseases/diagnosis, Bone Marrow Diseases/parasitology, Edema/pathology, Female, Granulocytes/parasitology, Granulocytes/pathology, Humans, Immunohistochemistry, Male, Megakaryocytes/parasitology, Megakaryocytes/pathology, Microscopy, Electron, Middle Aged, Toxoplasma/isolation & purification, Toxoplasmosis/diagnosis, Toxoplasmosis/parasitology
Pubmed
Web of science
Create date
13/10/2015 10:04
Last modification date
20/08/2019 16:47
Usage data