Viral integration and consequences on host gene expression

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Ressource 1Download: BIB_CCF4094E0956.P001.pdf (3359.22 [Ko])
State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_CCF4094E0956
Type
A part of a book
Publication sub-type
Chapter: chapter ou part
Collection
Publications
Institution
Title
Viral integration and consequences on host gene expression
Title of the book
Viruses: Essential Agents of Life
Author(s)
Desfarges S., Ciuffi A.
Publisher
Springer
Address of publication
Dordrecht
ISBN
978-94-007-4899-6
Publication state
Published
Issued date
2012
Editor
Witzany G.
Chapter
7
Pages
147-155
Language
english
Abstract
Upon cell infection, some viruses integrate their genome into the host
chromosome, either as part of their life cycle (such as retroviruses), or incidentally.
While possibly promoting long-term persistence of the virus into the cell, viral
genome integration may also lead to drastic consequences for the host cell, including
gene disruption, insertional mutagenesis and cell death, as well as contributing to
species evolution. This review summarizes the current knowledge on viruses integrating
their genome into the host genome and the consequences for the host cell.
Open Access
Yes
Create date
13/02/2013 15:31
Last modification date
20/08/2019 16:47
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