Effet du Naftidrofuryl (Praxilene) dans le glaucome primaire a angle ouvert (GPAO): etude prospective en double insu. [Effect of naftidrofuryl (Praxilene) in primary open angle glaucoma: prospective double-blind study]

Details

Serval ID
serval:BIB_CCEDC8D95868
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effet du Naftidrofuryl (Praxilene) dans le glaucome primaire a angle ouvert (GPAO): etude prospective en double insu. [Effect of naftidrofuryl (Praxilene) in primary open angle glaucoma: prospective double-blind study]
Journal
Klinische Monatsblatter fur Augenheilkunde
Author(s)
Beati  D., Mermoud  A., Faggioni  R.
ISSN
0023-2165 (Print)
Publication state
Published
Issued date
05/1992
Volume
200
Number
5
Pages
407-8
Notes
Clinical Trial
English Abstract
Journal Article
Randomized Controlled Trial --- Old month value: May
Abstract
The positive effect of Naftidrofuryl (Praxilene), a specific serotonine-S2 receptor antagonist, has already been described in the treatment of normal pressure glaucoma. Despite the fact that in POAG intraocular pressure (IOP) is the primary ethiopathogenic mechanism, vascular factors could also influence the progression of the disease, especially in old patients with cardiovascular risk factors. We have studied the effect of Naftidrofuryl versus placebo in a randomised double-blind study on 42 POAG patients. Visual acuity, IOP, Visual field (Octopus program G1), Arterial pressure, Plasma viscosity have been recorded at 0, 12 and 24 weeks. Our results showed no difference between the Naftidrofuryl and the Placebo group for each studied parameter except a decrease of CLV at 12 weeks in the Naftidrofuryl group (p = 0.012). This suggests that Naftidrofuryl is not as effective in POAG as it is in normal tension glaucoma. Other studies with a greater patient - collective and the use of other vasoactive substances will be necessary in the future.
Keywords
Aged Aged, 80 and over Double-Blind Method Female Glaucoma, Open-Angle/*drug therapy Humans Intraocular Pressure/drug effects Male Middle Aged Nafronyl/adverse effects/*therapeutic use Prospective Studies Visual Acuity/drug effects Visual Fields/drug effects
Pubmed
Web of science
Create date
28/01/2008 12:49
Last modification date
20/08/2019 15:47
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