Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology.

Details

Serval ID
serval:BIB_CCC3080DAFD6
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology.
Journal
Annual Review of Cell and Developmental Biology
Author(s)
Lemberger T., Desvergne B., Wahli W.
ISSN
1081-0706[print], 1081-0706[linking]
Publication state
Published
Issued date
1996
Volume
12
Pages
335-363
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors that belong to the steroid/thyroid/retinoic acid receptor superfamily. All their characterized target genes encode proteins that participate in lipid homeostasis. The recent finding that antidiabetic thiazolidinediones and adipogenic prostanoids are ligands of one of the PPARs reveals a novel signaling pathway that directly links these compounds to processes involved in glucose homeostasis and lipid metabolism including adipocyte differentiation. A detailed understanding of this pathway could designate PPARs as targets for the development of novel efficient treatments for several metabolic disorders.
Keywords
Amino Acid Sequence, Animals, Humans, Lipids/physiology, Microbodies/physiology, Molecular Sequence Data, Nuclear Proteins/physiology, Receptors, Cytoplasmic and Nuclear/physiology, Signal Transduction, Transcription Factors/physiology
Pubmed
Web of science
Create date
24/01/2008 16:26
Last modification date
20/08/2019 16:47
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