Apolipoprotein E4 effects on topological brain network organization in mild cognitive impairment.

Details

Serval ID
serval:BIB_CCB821B2CC5B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Apolipoprotein E4 effects on topological brain network organization in mild cognitive impairment.
Journal
Scientific reports
Author(s)
Sanabria-Diaz G., Melie-Garcia L., Draganski B., Demonet J.F., Kherif F.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
12/01/2021
Peer-reviewed
Oui
Volume
11
Number
1
Pages
845
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The Apolipoprotein E isoform E4 (ApoE4) is consistently associated with an elevated risk of developing late-onset Alzheimer's Disease (AD); however, less is known about the potential genetic modulation of the brain networks organization during prodromal stages like Mild Cognitive Impairment (MCI). To investigate this issue during this critical stage, we used a dataset with a cross-sectional sample of 253 MCI patients divided into ApoE4-positive (‛Carriers') and ApoE4-negative ('non-Carriers'). We estimated the cortical thickness (CT) from high-resolution T1-weighted structural magnetic images to calculate the correlation among anatomical regions across subjects and build the CT covariance networks (CT-Nets). The topological properties of CT-Nets were described through the graph theory approach. Specifically, our results showed a significant decrease in characteristic path length, clustering-index, local efficiency, global connectivity, modularity, and increased global efficiency for Carriers compared to non-Carriers. Overall, we found that ApoE4 in MCI shaped the topological organization of CT-Nets. Our results suggest that in the MCI stage, the ApoE4 disrupting the CT correlation between regions may be due to adaptive mechanisms to sustain the information transmission across distant brain regions to maintain the cognitive and behavioral abilities before the occurrence of the most severe symptoms.
Pubmed
Web of science
Open Access
Yes
Create date
14/01/2021 19:34
Last modification date
20/03/2021 7:22
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