IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice.

Details

Serval ID
serval:BIB_CC9FC3CDA3D9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice.
Journal
Nature Immunology
Author(s)
Biedermann T., Zimmermann S., Himmelrich H., Gumy A., Egeter O., Sakrauski A.K., Seegmüller I., Voigt H., Launois P., Levine A.D., Wagner H., Heeg K., Louis J.A., Röcken M.
ISSN
1529-2908 (Print)
ISSN-L
1529-2908
Publication state
Published
Issued date
2001
Volume
2
Number
11
Pages
1054-1060
Language
english
Abstract
Immunity to infection with intracellular pathogens is regulated by interleukin 12 (IL-12), which mediates protective T helper type 1 (TH1) responses, or IL-4, which induces TH2 cells and susceptibility. Paradoxically, we show here that when present during the initial activation of dendritic cells (DCs) by infectious agents, IL-4 instructed DCs to produce IL-12 and promote TH1 development. This TH1 response established resistance to Leishmania major in susceptible BALB/c mice. When present later, during the period of T cell priming, IL-4 induced TH2 differentiation and progressive leishmaniasis in resistant mice. Because immune responses developed via the consecutive activation of DCs and then T cells, the contrasting effects of IL-4 on DC development and T cell differentiation led to immune responses that had opposing functional phenotypes.
Keywords
Animals, Antigens, Protozoan/immunology, Cell Differentiation/drug effects, Cells, Cultured/drug effects, Dendritic Cells/drug effects, Dendritic Cells/immunology, Genetic Predisposition to Disease, Immunity, Innate, Interleukin-12/physiology, Interleukin-12/secretion, Interleukin-4/pharmacology, Interleukin-4/physiology, Leishmania major/immunology, Leishmania major/physiology, Leishmaniasis, Cutaneous/immunology, Mice, Mice, Inbred BALB C, Ovalbumin/immunology, Protozoan Proteins/immunology, Receptors, Antigen, T-Cell, alpha-beta/immunology, Recombinant Proteins/pharmacology, Specific Pathogen-Free Organisms, Th1 Cells/cytology, Th1 Cells/immunology, Th2 Cells/cytology, Th2 Cells/immunology, Time Factors
Pubmed
Web of science
Create date
28/01/2008 11:06
Last modification date
20/08/2019 15:47
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