Role of electrophysiological studies in predicting risk of ventricular arrhythmia in early repolarization syndrome.

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State: Public
Version: Final published version
Serval ID
serval:BIB_CC614B3B1703
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Role of electrophysiological studies in predicting risk of ventricular arrhythmia in early repolarization syndrome.
Journal
Journal of the American College of Cardiology
Author(s)
Mahida S., Derval N., Sacher F., Leenhardt A., Deisenhofer I., Babuty D., Schläpfer J., de Roy L., Frank R., Yli-Mayry S., Mabo P., Rostock T., Nogami A., Pasquié J.L., de Chillou C., Kautzner J., Jesel L., Maury P., Berte B., Yamashita S., Roten L., Lim H.S., Denis A., Bordachar P., Ritter P., Probst V., Hocini M., Jaïs P., Haïssaguerre M.
ISSN
1558-3597 (Electronic)
ISSN-L
0735-1097
Publication state
Published
Issued date
01/2015
Peer-reviewed
Oui
Volume
65
Number
2
Pages
151-159
Language
english
Notes
Publication types: Journal Article
Abstract
BACKGROUND: The early repolarization (ER) pattern is associated with an increased risk of arrhythmogenic sudden death. However, strategies for risk stratification of patients with the ER pattern are not fully defined.
OBJECTIVES: This study sought to determine the role of electrophysiology studies (EPS) in risk stratification of patients with ER syndrome.
METHODS: In a multicenter study, 81 patients with ER syndrome (age 36 ± 13 years, 60 males) and aborted sudden death due to ventricular fibrillation (VF) were included. EPS were performed following the index VF episode using a standard protocol. Inducibility was defined by the provocation of sustained VF. Patients were followed up by serial implantable cardioverter-defibrillator interrogations.
RESULTS: Despite a recent history of aborted sudden death, VF was inducible in only 18 of 81 (22%) patients. During follow-up of 7.0 ± 4.9 years, 6 of 18 (33%) patients with inducible VF during EPS experienced VF recurrences, whereas 21 of 63 (33%) patients who were noninducible experienced recurrent VF (p = 0.93). VF storm occurred in 3 patients from the inducible VF group and in 4 patients in the noninducible group. VF inducibility was not associated with maximum J-wave amplitude (VF inducible vs. VF noninducible; 0.23 ± 0.11 mV vs. 0.21 ± 0.11 mV; p = 0.42) or J-wave distribution (inferior, odds ratio [OR]: 0.96 [95% confidence interval (CI): 0.33 to 2.81]; p = 0.95; lateral, OR: 1.57 [95% CI: 0.35 to 7.04]; p = 0.56; inferior and lateral, OR: 0.83 [95% CI: 0.27 to 2.55]; p = 0.74), which have previously been demonstrated to predict outcome in patients with an ER pattern.
CONCLUSIONS: Our findings indicate that current programmed stimulation protocols do not enhance risk stratification in ER syndrome.
Pubmed
Web of science
Open Access
Yes
Create date
19/01/2015 19:24
Last modification date
20/08/2019 16:47
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