Diagnosis and current management of retinoblastoma

Details

Serval ID
serval:BIB_CC4E39D27E6B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Diagnosis and current management of retinoblastoma
Journal
Oncogene
Author(s)
Balmer  A., Zografos  L., Munier  F.
ISSN
0950-9232 (Print)
Publication state
Published
Issued date
08/2006
Volume
25
Number
38
Pages
5341-9
Notes
Journal Article
Review --- Old month value: Aug 28
Abstract
Retinoblastoma represents the prototypic model for inherited cancers. The RB1 gene was the first tumor suppressor gene to be identified. It represents the most frequent primary eye cancer in children under 15 years old, habitually occurring in infancy, even in utero, but can be observed in older children or young adults. Many other retinal lesions may also simulate retinoblastoma. The two major presenting signs are leukocoria and strabismus, but other ocular or general signs may be observed. A highly malignant tumor, retinoblastoma can nowadays be cured. The heritable form, however, carries a high risk of second nonocular tumors. Treatment in the early stages of disease holds a good prognosis for survival and salvage of visual function. In very late stages, however, the prognosis for ocular function and even survival is jeopardized.
Keywords
Cell Division *Genes, Retinoblastoma Humans Hyperthermia, Induced Neoplasm Metastasis Neoplasms, Second Primary/genetics Retinal Neoplasms/diagnosis/*genetics/pathology/therapy Retinoblastoma/diagnosis/*genetics/pathology/therapy
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 12:54
Last modification date
20/08/2019 15:47
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