Increased risk of cardiovascular disease (CVD) with age in HIV-positive men : a comparison of the D:A:D CVD risk equation and general population CVD risk equations
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Serval ID
serval:BIB_CC472650A74D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Increased risk of cardiovascular disease (CVD) with age in HIV-positive men : a comparison of the D:A:D CVD risk equation and general population CVD risk equations
Journal
Hiv Medicine
Working group(s)
D:A:D study group
Contributor(s)
Powderly B., Shortman N., Moecklinghoff C., Reilly G., Franquet X., Ryom L., Sabin CA., Kamara D., Smith C., Phillips A., Mocroft A., Tverland J., Mansfeld M., Nielsen J., Raben D., Lundgren J., Brandt£££R Salbøl£££ R. , Rickenbach M., Fanti I., Krum E., Hillebregt M., Geffard S., Sundström A., Delforge M., Fontas E., Torres F., McManus H., Wright S., Kjær J., Sjøl A., Meidahl P., Helweg- Larsen J., Iversen J., Ryom L., Mocroft A., Kirk O., Reiss P., Ross M., Fux C., Morlat P., Moranne O., Kesselring A., Kamara D., Smith C., Lundgren J., Smith C., Ryom L., Phillips A., Weber R., Morlat P., Pradier C., Reiss P., Friis-Møller N., Kowalska J., Lundgren J., Sabin C., Law M., d'Arminio Monforte A., Dabis F., Bruyand M., Reiss P., Smith C., Kamara D., Bower M., Fätkenheuer G., Donald A., Grulich A., Ryom L., Lundgren J., Reiss P., Zaheri S., Hillebregt M., Gras L., Prins J., Kuijpers T., Scherpbier H., van der Meer J., Wit F., Godfried M., Reiss P., van der Poll T., Nellen F., Lange J., Geerlings S., van Vugt M., Pajkrt D., Bos J., van der Valk M., Grijsen M., Wiersinga W., Goorhuis A., Hovius J., Lowe S., Lashof A., Posthouwer D., Pronk M., Ammerlaan H., van der Ende M., de Vries-Sluijs T., Schurink C., Nouwen J., Verbon A., Rijnders B., van Gorp E., van der Feltz M., Driessen G., van A., Branger J., Haag D., Schippers E., van Nieuwkoop C., van Elzakker E., Groeneveld P., Bouwhuis J., Soetekouw R., ten Kate R., Kroon F., van Dissel J., Arend S., de Boer M., Jolink H., Vollaard H., Bauer M., den Hollander J., Pogany K., van Twillert G., Kortmann W., Cohen Stuart J., Diederen B., Leyten E., Gelinck L., Kootstra G., Delsing C., Brinkman K., Blok W., Frissen P., Schouten W., van den Berk G., van Kasteren M., Brouwer A., Veenstra J., Lettinga K., Mulder J., Vrouenraets S., Lauw F., van Goyen, van Eeden A., Verhagen D., Sprenger H., Doedens R., Scholvinck E., van S., Bierman W., Koopmans P., Keuter M., van der Ven A., ter Hofstede H., Dofferhoff A., Warris A., van Crevel R., Hoepelman A., Mudrikova T., Schneider M., Ellerbroek P., Oosterheert J., Arends J., Wassenberg M., Barth R., van Agtmael M., Perenboom R., Claessen F., Bomers M., Peters E., Geelen S., Wolfs T., Bont L., Richter C., van der Berg J., Gisolf E., van den Berge M., Stegeman A., van Vonderen M., van Houte D., Weijer S., el Moussaoui R., Winkel C., Muskiet F., Voigt R., Dabis F., Bruyand M., Chêne G., Dabis F., Lawson-Ayayi S., Thiébaut R., Bonnal F., Bonnet F., Bernard N., Caunègre L., Cazanave C., Ceccaldi J., Chambon D., Chossat I., Dauchy F., De Witte S., Dupon M., Duffau P., Dutronc H., Farbos S., Gaborieau V., Gemain M., Gerard Y., Greib C., Hessamfar M., Lacoste D., Lataste P., Lafarie S., Lazaro E., Malvy D., Meraud J., Mercié P., Monlun E., Morlat P., Neau D., Ochoa A., Pellegrin J., Pistone T., Ragnaud J., Receveur M., Tchamgoué S., Vandenhende M., Viallard J., Moreau J., Pellegrin I., Fleury H., Lafon M., Masquelier B., Trimoulet P., Breilh D., Haramburu F., Miremont-Salamé G., Blaizeau M., Decoin M., Delaune J., Delveaux S., D'Ivernois C., Hanapier C., Leleux O., Uwamaliya-Nziyumvira B., Sicard X., Geffard S., Palmer G., Touchard D., Bonnet F., Dupon M., Mercié P., Morlat P., Pellegrin J., Ragnaud J., Dabis F., Law M., Petoumenos K., McManus H., Wright S., Bendall C., Moore R., Edwards S., Hoy J., Watson K., Roth N., Nicholson J., Bloch M., Franic T., Baker D., Vale R., Carr A., Cooper D., Chuah J., Ngieng M., Nolan D., Skett J., Calvo G., Torres F., Mateu S., Domingo P., A M., Gatell J., Del Cacho E., Cadafalch J., Fuster M., Codina C., Sirera G., Vaqué A., De Wit S., Clumeck N., Delforge M., Necsoi C., Clumeck N., De Wit S., Gennotte A., Gerard M., Kabeya K., Konopnicki D., Libois A., Martin C., Payen M., Semaille P., Van Laethem Y., Neaton J., Bartsch G., El-Sadr W., Krum E., Thompson G., Wentworth D., Luskin-Hawk R., Telzak E., El-Sadr W., Abrams D., Cohn D., Markowitz N., Arduino R., Mushatt D., Friedland G., Perez G., Tedaldi E., Fisher E., Gordin F., Crane L., Sampson J., Baxter J., Lundgren J., Kirk O., Mocroft A., Cozzi-Lepri A., Grint D., Podlekareva D., Kjær J., Peters L., Reekie J., Kowalska J., Tverland J., Fischer A., Nielsen J., Losso M., Elias C., Ramos JM., Vetter N., Zangerle R., Karpov I., Vassilenko A., Mitsura V., Suetnov O., Clumeck N., De Wit S., Delforge M., Colebunders R., Vandekerckhove L., Hadziosmanovic V., Kostov K., Begovac J., Machala L., Jilich D., Sedlacek D., Nielsen J., Kronborg G., Benfield T., Larsen M., Gerstoft J., Katzenstein T., Hansen A-., Skinhøj P., Pedersen C., Ostergaard L., Zilmer K., Smidt J., Ristola M., Katlama C., Viard J-., Girard P-., Livrozet J., Vanhems P., Bernard C., Pradier C., Dabis F., Neau D., Rockstroh J., Schmidt R., van Lunzen J., Degen O., Stellbrink H., Staszewski S., Goethe JW., Bickel M., Kosmidis J., Gargalianos P., Xylomenos G., Perdios J., Panos G., Filandras A., Karabatsaki E., Sambatakou H., Banhegyi D., Mulcahy F., Yust I., Turner D., Burke M., Pollack S., Hassoun G., Maayan S., Vella S., Esposito R., Mazeu I., Mussini C., Arici C., Pristera R., Mazzotta F., Gabbuti A., Vullo V., Lichtner M., Chirianni A., Montesarchio E., Gargiulo M., Cotugno AD., Antonucci G., Testa A., Narciso P., Vlassi C., Zaccarelli M., Lazzarin A., Castagna A., Gianotti N., Galli M., Ridolfo A., Sacco L., d'Arminio Monforte A., Rozentale B., Zeltina I., Chaplinskas S., Hemmer R., Staub T., Reiss P., Ormaasen V., Maeland A., Bruun J., Knysz B., Gasiorowski J., Horban A., Bakowska E., Grzeszczuk A., Flisiak R., Boron- Kaczmarska A., Pynka M., Parczewski M., Beniowski M., Mularska E., Trocha H., Jablonowska E., Malolepsza E., Wojcik K., Antunes F., Doroana M., Caldeira L., Mansinho K., Maltez F., Duiculescu D., Rakhmanova A., Zakharova N., Buzunova S., Jevtovic D., Mokrá? M. , Staneková D., Tomazic J., González-Lahoz J., Soriano V., Labarga P., Medrano J., Moreno S., Rodriguez J., Clotet B., Jou A., Paredes R., Tural C., Puig J., Bravo I., Gatell J., M J., Domingo P., Gutierrez M., Mateo G., Sambeat M., Karlsson A., Flamholc L., Ledergerber B., Weber R., Francioli P., Cavassini M., Hirschel B., Boffi E., Furrer H., Battegay M., Elzi L., Kravchenko E., Chentsova N., Frolov V., Kutsyna G., Servitskiy S., Krasnov M., Barton S., Johnson A., Mercey D., Phillips A., Johnson M., Mocroft A., Murphy M., Weber J., Scullard G., Fisher M., Leen C., Morfeldt L., Thulin G., Sundström A., Åkerlund B., Koppel K., Karlsson A., Flamholc L., Håkangård C., Moroni M., Angarano G., Antinori A., Armignacco O., d'Arminio Monforte A., Castelli F., Cauda R., Di Perri G., Galli M., Iardino R., Ippolito G., Lazzarin A., Perno C., von Schloesser F., Viale P., d'Arminio Monforte A., Antinori A., Castagna A., Ceccherini-Silberstein F., Cozzi-Lepri A., Girardi E., Lo Caputo S., Mussini C., Puoti M., Andreoni M., Ammassari A., Antinori A., d'rminio Monforte A., Balotta C., Bonfanti P., Bonora S., Borderi M., Capobianchi M., Castagna A., Ceccherini-Silberstein F., Cingolani A., Cinque P., Cozzi-Lepri A., De Luca A., Di Biagio A., Girardi E., Gianotti N., Gori A., Guaraldi G., Lapadula G., Lichtner M., Caputo S., Madeddu G., Maggiolo F., Marchetti G., Marcotullio S., Monno L., Mussini C., Puoti M., Roldan E., Rusconi S., Cozzi-Lepri A., Cicconi P., Fanti I., Formenti T., Galli L., Lorenzini P., Giacometti A., Costantini A., Angarano G., Monno L., Santoro C., Maggiolo F., Suardi C., Viale P., Vanino E., Verucchi G., Castelli F., Quiros Roldan E., Minardi C., Quirino T., Abeli C., Manconi P., Piano P., Vecchiet J., Falasca K., Sighinolfi L., Segala D., Mazzotta F., Lo Caputo S., Cassola G., Viscoli G., Alessandrini A., Piscopo R., Mazzarello G., Mastroianni C., Belvisi V., Bonfanti P., Caramma I., Castelli A., Galli M., Lazzarin A., Rizzardini G., Puoti M., d'Arminio Monforte A., Ridolfo A., Piolini R., Castagna A., Salpietro S., Carenzi L., Moioli M., Cicconi P., Marchetti G., Mussini C., Puzzolante C., Gori A., Lapadula G., Abrescia N., Chirianni A., Guida M., Onofrio M., Baldelli F., Francisci D., Parruti G., Ursini T., Magnani G., Ursitti M., Cauda R., Andreoni M., Antinori A., Vullo V., Cingolani A., d'Avino A., Ammassari A., Gallo L., Nicastri E., Acinapura R., Capozzi M., Libertone R., Tebano G., Cattelan A., Mura M., Madeddu G., Caramello P., Di Perri G., Orofino G., Bonora S., Sciandra M., Pellizzer G., Manfrin V., Pradier C., Fontas E., Caissotti C., Dellamonica P., Bernard E., Cua E., De Salvador-Guillouet F., Durant J., Ferrando S., Mondain-Miton V., Naqvi A., Perbost I., Prouvost-Keller B., Pillet S., Pugliese P., Rahelinirina V., Roger P., Dollet K., Aubert V., Barth J., Battegay M., Bernasconi E., Böni J., Bucher H., Burton-Jeangros C., Calmy A., Cavassini M., Egger M., Elzi L., Fehr J., Fellay J., Furrer H., Fux C., Gorgievski M., Günthard H., Haerry D., Hasse B., Hirsch H., Hösli I., Kahlert C., Kaiser L., Keiser O., Klimkait T., Kovari H., Ledergerber B., Martinetti G., de Tejada B., Metzner K., Müller N., Nadal D., Pantaleo G., Rauch A., Regenass S., Rickenbach M., Rudin C., Schmid P., Schultze D., Schöni-Affolter F., Schüpbach J., Speck R., Taffé P., Tarr P., Telenti A., Trkola A., Vernazza P., Weber R., Yerly S.
ISSN
1468-1293 (Electronic)
ISSN-L
1464-2662
Publication state
Published
Issued date
2014
Volume
15
Number
10
Pages
595-603
Language
english
Notes
Publication types: Journal Article ; Observational Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
Abstract
OBJECTIVES: The aim of the study was to statistically model the relative increased risk of cardiovascular disease (CVD) per year older in Data collection on Adverse events of anti-HIV Drugs (D:A:D) and to compare this with the relative increased risk of CVD per year older in general population risk equations.
METHODS: We analysed three endpoints: myocardial infarction (MI), coronary heart disease (CHD: MI or invasive coronary procedure) and CVD (CHD or stroke). We fitted a number of parametric age effects, adjusting for known risk factors and antiretroviral therapy (ART) use. The best-fitting age effect was determined using the Akaike information criterion. We compared the ageing effect from D:A:D with that from the general population risk equations: the Framingham Heart Study, CUORE and ASSIGN risk scores.
RESULTS: A total of 24 323 men were included in analyses. Crude MI, CHD and CVD event rates per 1000 person-years increased from 2.29, 3.11 and 3.65 in those aged 40-45 years to 6.53, 11.91 and 15.89 in those aged 60-65 years, respectively. The best-fitting models included inverse age for MI and age + age(2) for CHD and CVD. In D:A:D there was a slowly accelerating increased risk of CHD and CVD per year older, which appeared to be only modest yet was consistently raised compared with the risk in the general population. The relative risk of MI with age was not different between D:A:D and the general population.
CONCLUSIONS: We found only limited evidence of accelerating increased risk of CVD with age in D:A:D compared with the general population. The absolute risk of CVD associated with HIV infection remains uncertain.
METHODS: We analysed three endpoints: myocardial infarction (MI), coronary heart disease (CHD: MI or invasive coronary procedure) and CVD (CHD or stroke). We fitted a number of parametric age effects, adjusting for known risk factors and antiretroviral therapy (ART) use. The best-fitting age effect was determined using the Akaike information criterion. We compared the ageing effect from D:A:D with that from the general population risk equations: the Framingham Heart Study, CUORE and ASSIGN risk scores.
RESULTS: A total of 24 323 men were included in analyses. Crude MI, CHD and CVD event rates per 1000 person-years increased from 2.29, 3.11 and 3.65 in those aged 40-45 years to 6.53, 11.91 and 15.89 in those aged 60-65 years, respectively. The best-fitting models included inverse age for MI and age + age(2) for CHD and CVD. In D:A:D there was a slowly accelerating increased risk of CHD and CVD per year older, which appeared to be only modest yet was consistently raised compared with the risk in the general population. The relative risk of MI with age was not different between D:A:D and the general population.
CONCLUSIONS: We found only limited evidence of accelerating increased risk of CVD with age in D:A:D compared with the general population. The absolute risk of CVD associated with HIV infection remains uncertain.
Keywords
Adult, Age Factors, Aged, Anti-HIV Agents/adverse effects, Coronary Disease/etiology, HIV Infections/complications, HIV Infections/drug therapy, Humans, Male, Middle Aged, Myocardial Infarction/etiology, Prospective Studies, Regression Analysis, Risk Factors, Stroke/etiology
Pubmed
Web of science
Open Access
Yes
Create date
02/06/2015 15:17
Last modification date
20/08/2019 15:46
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