Glycogen storage capacity and de novo lipogenesis during massive carbohydrate overfeeding in man.
Details
Serval ID
serval:BIB_CC16E53BB20D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Glycogen storage capacity and de novo lipogenesis during massive carbohydrate overfeeding in man.
Journal
American Journal of Clinical Nutrition
ISSN
0002-9165 (Print)
ISSN-L
0002-9165
Publication state
Published
Issued date
1988
Volume
48
Number
2
Pages
240-247
Language
english
Abstract
The metabolic balance method was performed on three men to investigate the fate of large excesses of carbohydrate. Glycogen stores, which were first depleted by diet (3 d, 8.35 +/- 0.27 MJ [1994 +/- 65 kcal] decreasing to 5.70 +/- 1.03 MJ [1361 +/- 247 kcal], 15% protein, 75% fat, 10% carbohydrate) and exercise, were repleted during 7 d carbohydrate overfeeding (11% protein, 3% fat, and 86% carbohydrate) providing 15.25 +/- 1.10 MJ (3642 +/- 263 kcal) on the first day, increasing progressively to 20.64 +/- 1.30 MJ (4930 +/- 311 kcal) on the last day of overfeeding. Glycogen depletion was again accomplished with 2 d of carbohydrate restriction (2.52 MJ/d [602 kcal/d], 85% protein, and 15% fat). Glycogen storage capacity in man is approximately 15 g/kg body weight and can accommodate a gain of approximately 500 g before net lipid synthesis contributes to increasing body fat mass. When the glycogen stores are saturated, massive intakes of carbohydrate are disposed of by high carbohydrate-oxidation rates and substantial de novo lipid synthesis (150 g lipid/d using approximately 475 g CHO/d) without postabsorptive hyperglycemia.
Keywords
Adult, Body Composition, Calorimetry, Indirect, Dietary Carbohydrates/administration & dosage, Eating Disorders/metabolism, Energy Intake, Energy Metabolism, Glycogen/metabolism, Humans, Hyperphagia/metabolism, Lipids/biosynthesis, Male, Reference Values
Pubmed
Web of science
Create date
21/01/2008 14:09
Last modification date
20/08/2019 16:46