The Complex Hodological Architecture of the Macaque Dorsal Intraparietal Areas as Emerging from Neural Tracers and DW-MRI Tractography.

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License: CC BY 4.0
Serval ID
serval:BIB_CC10648A563B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The Complex Hodological Architecture of the Macaque Dorsal Intraparietal Areas as Emerging from Neural Tracers and DW-MRI Tractography.
Journal
eNeuro
Author(s)
Caminiti R., Girard G., Battaglia-Mayer A., Borra E., Schito A., Innocenti G.M., Luppino G.
ISSN
2373-2822 (Electronic)
ISSN-L
2373-2822
Publication state
Published
Issued date
2021
Peer-reviewed
Oui
Volume
8
Number
4
Pages
0102-21.2021
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
In macaque monkeys, dorsal intraparietal areas are involved in several daily visuomotor actions. However, their border and sources of cortical afferents remain loosely defined. Combining retrograde histologic tracing and MRI diffusion-based tractography, we found a complex hodology of the dorsal bank of the intraparietal sulcus (db-IPS), which can be subdivided into a rostral intraparietal area PEip, projecting to the spinal cord, and a caudal medial intraparietal area MIP lacking such projections. Both include an anterior and a posterior sector, emerging from their ipsilateral, gradient-like connectivity profiles. As tractography estimations, we used the cross-sectional area of the white matter bundles connecting each area with other parietal and frontal regions, after selecting regions of interest (ROIs) corresponding to the injection sites of neural tracers. For most connections, we found a significant correlation between the proportions of cells projecting to all sectors of PEip and MIP along the continuum of the db-IPS and tractography. The latter also revealed "false positive" but plausible connections awaiting histologic validation.
Keywords
Animals, Brain Mapping, Diffusion Magnetic Resonance Imaging, Frontal Lobe, Macaca fascicularis, Neural Pathways/diagnostic imaging, Parietal Lobe/diagnostic imaging, White Matter/diagnostic imaging, cortico-cortical connections, diffusion tractography, frontal cortex, intraparietal sulcus, macaque brain, parietal cortex
Pubmed
Web of science
Open Access
Yes
Create date
15/06/2021 11:57
Last modification date
08/08/2024 7:40
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