The potential of cystatin C as a predictive biomarker in breast cancer.

Details

Serval ID
serval:BIB_CBEEEEB8C55E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The potential of cystatin C as a predictive biomarker in breast cancer.
Journal
Expert review of anticancer therapy
Author(s)
Leto G., Sepporta M.V.
ISSN
1744-8328 (Electronic)
ISSN-L
1473-7140
Publication state
Published
Issued date
12/2020
Peer-reviewed
Oui
Volume
20
Number
12
Pages
1049-1056
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Breast cancer (BCa) is the leading cause of cancer-related deaths among women. Numerous efforts are being directed toward identifying novel tissue and/or circulating molecular markers that may help clinicians in detecting early-stage BCa patients and in providing an accurate estimation of the prognosis and prediction of response to clinical treatments. In this setting, emerging evidence has indicated Cystatin C (Cyst C), as the most potent endogenous inhibitor of cysteine cathepsins, as a possible useful marker in the clinical management of BCa patients.
This review analyzes the results of emerging studies underpinning a potential clinical role of Cyst C, as additional marker in BCa.
Cyst C expression levels have been reported to be altered in tumor tissues and/or in biological fluids of BCa patients. Furthermore, clinical evidence has highlighted a significant correlation between altered Cyst C levels in tumor tissues and/or biological fluids and some clinco-biological parameters of BCa progression. These findings provide evidence for a potential clinical use of Cyst C as a novel marker to improve the clinical and therapeutic management of BCa patients and as a gauge for better clarifying the role of cysteine proteinases in the various steps of BCa progression.
Keywords
Animals, Biomarkers, Tumor/metabolism, Breast Neoplasms/pathology, Cystatin C/metabolism, Disease Progression, Female, Humans, Neoplasm Staging, Prognosis, Breast cancer, cathepsins, cystatin C, cystatins, cysteine proteinases, metastasis, proteinase inhibitors, tumor markers, tumor progression
Pubmed
Web of science
Create date
02/10/2020 13:54
Last modification date
16/04/2024 7:11
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