Impact of intracranial pressure and cerebral perfusion pressure on severe disability and mortality after head injury.

Details

Serval ID
serval:BIB_CBE4C18382AD
Type
Article: article from journal or magazin.
Collection
Publications
Title
Impact of intracranial pressure and cerebral perfusion pressure on severe disability and mortality after head injury.
Journal
Neurocritical Care
Author(s)
Balestreri M., Czosnyka M., Hutchinson P., Steiner L.A., Hiler M., Smielewski P., Pickard J.D.
ISSN
1541-6933
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
4
Number
1
Pages
8-13
Language
english
Abstract
OBJECTIVE: To investigate the relationships between intracranial pressure (ICP), cerebral perfusion pressure (CPP), and outcome after traumatic brain injury. MATERIAL AND METHODS: A retrospective analysis of prospectively recorded data from 429 patients after head injury requiring intensive treatment on the Neuroscience Intensive Annex and the Neuro Critical Care Unit, Cambridge, UK. ICP, CPP, and arterial blood pressure (ABP) were continuously recorded. Mean values of pressures were compared to outcome assessed at 6 months after injury (using the Glasgow Outcome Scale). RESULTS: The mortality rate was greater in those having mean ICP greater than 20 mmHg (17% below versus 47% above; p < 0.0001). The mortality rate was dramatically increased for CPP below 55 mmHg (81% below versus 23% above; p < 0.0001). For values of CPP greater than 95 mmHg, favorable outcome was less frequent (50% below versus 28% above; p < 0.033). The rate of severe disability showed the tendency to increase with CPP ( r = 0.87; p = 0.02), suggesting that a higher CPP does not help in achieving favorable outcomes. ICP was greater in those who died in comparison to those who survived (27 +/- 19 mmHg versus 16 +/- 6 mmHg; p < 0.10 - 7), and CPP was lower (68 +/- 21 versus 76 +/- 10 mmHg; p < 0.0002). There was no difference between mean ICP and CPP in good/moderate and severe disability outcome groups. CONCLUSION: High ICP is strongly associated with fatal outcome. Excessive CPP seems to reduce the probability of achieving a favorable outcome following head trauma.
Keywords
Adolescent, Adult, Blood Pressure/physiology, Brain Injuries/complications, Brain Injuries/mortality, Cerebrovascular Circulation/physiology, Female, Humans, Intracranial Pressure/physiology, Male, Middle Aged, Monitoring, Physiologic, Retrospective Studies, Survival Rate, Treatment Outcome
Pubmed
Web of science
Create date
10/12/2009 15:40
Last modification date
20/08/2019 15:46
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