LIGHT/HVEM/LTβR interaction as a target for the modulation of the allogeneic immune response in transplantation.

Details

Serval ID
serval:BIB_CBD8A5AA85E7
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
LIGHT/HVEM/LTβR interaction as a target for the modulation of the allogeneic immune response in transplantation.
Journal
American Journal of Transplantation
Author(s)
del Rio M.L., Schneider P., Fernandez-Renedo C., Perez-Simon J.A., Rodriguez-Barbosa J.I.
ISSN
1600-6143 (Electronic)
ISSN-L
1600-6135
Publication state
Published
Issued date
2013
Volume
13
Number
3
Pages
541-551
Language
english
Abstract
The exchange of information during interactions of T cells with dendritic cells, B cells or other T cells regulates the course of T, B and DC-cell activation and their differentiation into effector cells. The tumor necrosis factor superfamily member LIGHT (homologous to lymphotoxin, exhibits inducible expression and competes with HSV glycoprotein D for binding to herpesvirus entry mediator, a receptor expressed on T lymphocytes) is transiently expressed upon T cell activation and modulates CD8 T cell-mediated alloreactive responses upon herpes virus entry mediator (HVEM) and lymphotoxin β receptor (LTβR) engagement. LIGHT-deficient mice, or WT mice treated with LIGHT-targeting decoy receptors HVEM-Ig, LTβR-Ig or sDcR3-Ig, exhibit prolonged graft survival compared to untreated controls, suggesting that LIGHT modulates the course and severity of graft rejection. Therefore, targeting the interaction of LIGHT with HVEM and/or LTβR using recombinant soluble decoy receptors or monoclonal antibodies represent an innovative therapeutic strategy for the prevention and treatment of allograft rejection and for the promotion of donor-specific tolerance.
Keywords
Coinhibition, costimulation, HVEM, LIGHT, LT R, transplantation
Pubmed
Web of science
Open Access
Yes
Create date
08/04/2013 10:43
Last modification date
20/08/2019 16:46
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