Peroxisome Proliferator Activated Receptor Gamma Controls Mature Brown Adipocyte Inducibility through Glycerol Kinase.

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State: Public
Version: Final published version
Serval ID
serval:BIB_CBCB32BF2113
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Peroxisome Proliferator Activated Receptor Gamma Controls Mature Brown Adipocyte Inducibility through Glycerol Kinase.
Journal
Cell reports
Author(s)
Lasar D., Rosenwald M., Kiehlmann E., Balaz M., Tall B., Opitz L., Lidell M.E., Zamboni N., Krznar P., Sun W., Varga L., Stefanicka P., Ukropec J., Nuutila P., Virtanen K., Amri E.Z., Enerbäck S., Wahli W., Wolfrum C.
ISSN
2211-1247 (Electronic)
Publication state
Published
Issued date
16/01/2018
Peer-reviewed
Oui
Volume
22
Number
3
Pages
760-773
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Peroxisome proliferator-activated receptors (PPARs) have been suggested as the master regulators of adipose tissue formation. However, their role in regulating brown fat functionality has not been resolved. To address this question, we generated mice with inducible brown fat-specific deletions of PPARα, β/δ, and γ, respectively. We found that both PPARα and β/δδ are dispensable for brown fat function. In contrast, we could show that ablation of PPARγ in vitro and in vivo led to a reduced thermogenic capacity accompanied by a loss of inducibility by β-adrenergic signaling, as well as a shift from oxidative fatty acid metabolism to glucose utilization. We identified glycerol kinase (Gyk) as a partial mediator of PPARγ function and could show that Gyk expression correlates with brown fat thermogenic capacity in human brown fat biopsies. Thus, Gyk might constitute the link between PPARγ-mediated regulation of brown fat function and activation by β-adrenergic signaling.
Keywords
Adipocytes/cytology, Adipocytes/enzymology, Adipocytes/metabolism, Adipose Tissue, Brown/cytology, Adipose Tissue, Brown/enzymology, Adipose Tissue, Brown/metabolism, Adult, Animals, Female, Glycerol Kinase/metabolism, Humans, Male, Mice, Mice, Inbred C57BL, PPAR gamma/metabolism, Thermogenesis, PPAR alpha, PPAR gamma, brown adipose tissue, glycerol kinase, non-shivering thermogenesis
Pubmed
Web of science
Open Access
Yes
Create date
27/01/2018 14:18
Last modification date
20/08/2019 16:46
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