Well-differentiated liposarcomas and dedifferentiated liposarcomas: Systemic treatment options for two sibling neoplasms.

Details

Serval ID
serval:BIB_CB408536C633
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Well-differentiated liposarcomas and dedifferentiated liposarcomas: Systemic treatment options for two sibling neoplasms.
Journal
Cancer treatment reviews
Author(s)
Kyriazoglou A., Pagkali A., Kotsantis I., Economopoulou P., Kyrkasiadou M., Moutafi M., Gavrielatou N., Anastasiou M., Boulouta A., Pantazopoulos A., Giannakakou M., Digklia A., Psyrri A.
ISSN
1532-1967 (Electronic)
ISSN-L
0305-7372
Publication state
Published
Issued date
04/2024
Peer-reviewed
Oui
Volume
125
Pages
102716
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Well-differentiated liposarcomas (WDLPS) and dedifferentiated liposarcomas (DDLPS) account for 60 % of all liposarcomas, reflecting the heterogeneity of this type of sarcoma. Genetically, both types of liposarcomas are characterized by the amplification of MDM2 and CDK4 genes, which indicates an important molecular event with diagnostic and therapeutic relevance. In both localized WDLPS and DDLPS of the retroperitoneum and the extremities, between 25 % and 30 % of patients have local or distant recurrence, even when perioperatively treated, with clear margins present. The systemic treatment of WDLPS and DDLPS remains a challenge, with anthracyclines as the gold standard for first-line treatment. Several regimens have been tested with modest results regarding their efficacy. Herein we discuss the systemic treatment options for WDLPS and DDLPS and review their reported clinical efficacy results.
Keywords
Humans, Siblings, Liposarcoma/drug therapy, Liposarcoma/genetics, Soft Tissue Neoplasms/diagnosis, Treatment Outcome, Proto-Oncogene Proteins c-mdm2/genetics, Proto-Oncogene Proteins c-mdm2/therapeutic use, Dedifferentiated liposarcoma, Immunotherapy, Systemic treatment, Targeted therapy, Well-differentiated liposarcoma
Pubmed
Web of science
Create date
22/03/2024 14:45
Last modification date
14/05/2024 8:10
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