Local Adipose-Associated Mediators and Adaptations Following Arteriovenous Fistula Creation.

Details

Serval ID
serval:BIB_CB3EA5756B8D
Type
Article: article from journal or magazin.
Collection
Publications
Title
Local Adipose-Associated Mediators and Adaptations Following Arteriovenous Fistula Creation.
Journal
Kidney international reports
Author(s)
Sharma G., Kuppler C., He Y., Tao M., Ding K., Longchamp A., Dember L.M., Ozaki C.K., Berceli S.A.
ISSN
2468-0249 (Electronic)
ISSN-L
2468-0249
Publication state
Published
Issued date
07/2018
Peer-reviewed
Oui
Volume
3
Number
4
Pages
970-978
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Local inflammation is an important regulator of vascular remodeling. We hypothesized that adipose tissue adjacent to hemodialysis arteriovenous fistulae modulates maturation.
During fistula creation, perivenous adipose was collected from 111 participants in the Hemodialysis Fistula Maturation Study. Nine adipose-associated mediators were measured. Duplex ultrasound was performed at 4 time points postoperatively from 1 day to first cannulation (10-26 weeks). Associations between logarithmically transformed biomarker levels and fistula remodeling were evaluated using mixed effects regression.
Elevated interleukin (IL)-6 and monocyte chemoattractant protein (MCP)-1 were associated with a reduction in the fractional vein diameter during the early time frame of 1 day to 2 weeks (diameter change of 26.6% and 20.4% at the 25th and 75th percentile for IL-6, P = 0.01; 27.8% and 21.1% at the 25th and 75th percentile for MCP-1, P = 0.02), but not in later stages of remodeling. Local leptin levels showed a significant negative correlation with fractional venous flow increase between 2 and 6 weeks (percent flow change 31.4% and 11.3% at the 25th and 75th percentile for leptin, P = 0.03).
Thus, impaired fistula vein dilation and reduced capacity for flow augmentation associate with specific local adipose phenotypic signatures in a time-dependent manner. In view of adipose tissue plasticity, these findings raise the possibility of novel adipose-based strategies to facilitate fistula maturation.
Keywords
chronic kidney disease, fistula maturation, hemodialysis, inflammation, perivascular adipose tissue
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / Careers / P1LAP3_158895
Create date
07/03/2021 13:37
Last modification date
08/03/2021 7:26
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