Heparin removal after cardiopulmonary bypass in a patient with adverse reaction to protamine

Details

Serval ID
serval:BIB_CB1764F13FAB
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Heparin removal after cardiopulmonary bypass in a patient with adverse reaction to protamine
Journal
Thoracic and Cardiovascular Surgeon
Author(s)
Tevaearai  H. T., Jegger  D., Mueller  X. M., Horisberger  J., von Segesser  L. K.
ISSN
0171-6425 (Print)
Publication state
Published
Issued date
10/1998
Volume
46
Number
5
Pages
303-4
Notes
Case Reports
Journal Article --- Old month value: Oct
Abstract
A 74-year-old man underwent elective coronary surgery under cardiopulmonary bypass. A few minutes after the protamine administration was started, he suddenly developed a severe hypotension necessitating cardiac massage and recannulation for pump assistance. A further test dose of protamine provoked an identical reaction. We installed a Heparin Removal Device, which allows for ex-vivo deheparinization. In 35 minutes ACT decreased from 480 sec to 180 sec and clots appeared in the operating field. This system provides an excellent alternative to protamine in patients with an adverse reaction to protamine.
Keywords
Aged *Cardiopulmonary Bypass *Coronary Artery Bypass Extracorporeal Circulation/*instrumentation Heparin Antagonists/*adverse effects Humans Male Plasmapheresis/*instrumentation Protamines/*adverse effects
Pubmed
Web of science
Create date
28/01/2008 10:28
Last modification date
20/08/2019 16:45
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